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Environmental Water Analysis: Expand Your Toolbox

Environmental analysis of water samples is often an underappreciated aspect of monitoring or processing infrastructure. Click to read more. ....

Time Of Flight Mass Spectrometry , Target Analysis , Non Target Screening , Electron Ionisation , Positive Chemical Ionisation , Negative Chemical Ionisation ,

"Characterization of microchannel plate detector response for the detec" by Anjusha Mathew, Gert B. Eijkel et al.

Time-of-flight (TOF) systems are one of the most widely used mass analyzers in native mass spectrometry (nMS) for the analysis of non-covalent multiply charged bio-macromolecular assemblies (MMAs). Typically, microchannel plates (MCPs) are employed for high mass native ion detection in TOF MS. MCPs are well known for their reduced detection efficiency when impinged by large slow moving ions. Here, a position- and time-sensitive Timepix (TPX) detector has been added to the back of a dual MCP stack to study the key factors that affect MCP performance for MMA ions generated by nMS. The footprint size of the secondary electron cloud generated by the MCP on the TPX for each individual ion event is analyzed as a measure of MCP performance at each mass-to-charge (m/z) value and resulted in a Poisson distribution. This allowed us to investigate the dependency of ion mass, ion charge, ion velocity, acceleration voltage, and MCP bias voltage on MCP response in the high mass low velocity regime. ....

Microchannel Plate Detector , Ative Mass Spectrometry , Ingle Ion Imaging , Time Of Flight Mass Spectrometry , Imepix Detector ,