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Updated Data Continue to Aid IO-Based Frontline Treatment Decisions in Advanced RCC

Tian Zhang, MD, MHS, details how updated data presented at the 2023 ASCO Annual Meeting from trials such as KEYNOTE-426 and CLEAR have showed the sustained efficacy of VEGF plus immunotherapy combinations vs sunitinib in the first-line setting; discusses where the immunotherapy-only combination of ipilimumab and nivolumab fits in the frontline setting; and highlights how data from CONTACT-03 provided key insights on the use of immunotherapy in patients with advanced renal cell carcinoma after progression on a prior immune checkpoint inhibitor. ....

United States , Raquibul Hannan , Department Of Internal Medicine , Tian Zhang , Science Summit , Hans Hammers , Internal Medicine , Comprehensive Cancer Center , Immunotherapy In Gu Cancers , Genitourinary Cancers , Immuno Oncology ,

Molecular Subtyping and Surgical Sequencing Broaden Immunotherapy Applications in RCC

Tian Zhang, MD, discusses unanswered questions regarding molecular drivers of kidney cancer that the OPTIC RCC trial aims to answer, next steps with this research, and the potential benefits of receiving systemic therapy prior to undergoing cytoreductive nephrectomy for patients with metastatic renal cell carcinoma. ....

United States , Damla Gunenc , Williamg Kaelyn Jr , Brian Rini , Kidney Cancer Research Summit , Department Of Defense , Department Of Internal Medicine , Tian Zhang , Cancer Research , Internal Medicine , Medical Center Harold , Comprehensive Cancer Center , Renal Cell Carcinoma ,