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EV-302 Regimen Bests Chemo in Advanced Urothelial Cancer

Findings from the EV-302 trial presented at the 2023 ESMO Congress revealed that the combination of enfortumab vedotin and pembrolizumab may become the preferred frontline standard of care for patients with locally advanced or metastatic urothelial cancer regardless of cisplatin eligibility. ....

City Of , United Kingdom , Thomasb Powles , Barts Cancer Centre At St Bartholomew Hospital , Barts Cancer Centre , Frontline Treatment , Ev 302 , Urothelial Cancer , Ev 302 Keynote A39 Trial , Enfortumab Vedotin And Pembrolizumab ,

Enfortumab Vedotin Plus Pembrolizumab Nearly Doubles PFS, OS in Bladder Cancer

Enfortumab vedotin plus pembrolizumab improved survival outcomes over chemotherapy in previously untreated, advanced bladder cancer. ....

United Kingdom , Astellas Pharma , Thomasb Powles , Merck Sharp Dohme , Seagen Inc , Barts Cancer Institute , Queen Mary University , Merck Sharp ,

Padcev Plus Keytruda Reduces Risk of Death, Disease Progression in Advanced Bladder Cancer

For the first time, a drug combination (Padcev plus Keytruda) outperformed frontline chemotherapy for patients with locally advanced or metastatic urothelial carcinoma. ....

City Of , United Kingdom , Thomasb Powles , Barts Cancer Centre At St , Barts Cancer Centre , Bladder Cancer , Esmo 2023 ,

Frontline Enfortumab Vedotin Plus Pembrolizumab Elicits OS Improvement in Advanced Urothelial Carcinoma

Frontline treatment with the combination of enfortumab vedotin-ejfv and pembrolizumab led to a statistically significant improvement in overall survival vs chemotherapy in patients with previously untreated locally advanced or metastatic urothelial carcinoma. ....

City Of , United Kingdom , Thomasb Powles , Barts Cancer Centre At St , Barts Cancer Centre , Urothelial Carcinoma , Enfortumab Vedotin , Esmo Congress ,