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Cold temps may help to combat obesity by reducing inflammation

Cold temps may help to combat obesity by reducing inflammation
scienceblog.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from scienceblog.com Daily Mail and Mail on Sunday newspapers.

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Cold temps may help to combat obesity and related metabolic diseases by reducing inflammation, researchers find

Cold temps may help to combat obesity and related metabolic diseases by reducing inflammation, researchers find
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

United States , Chih Hao Wang , Briane Sansbury , Justin Darcy , Rudolphe Tanzi , Lauriej Goodyear , Seand Kodani , Aaronm Cypess , Nayara Pereira , Satoru Sugimoto , Hebe Agustina Mena , Yu Hua Tseng , Shio Kobayashi , Tadataka Tsuji , Gerson Profeta , Thomas Serwold , Joji Kusuyama , National Institute Of Diabetes , Beth Israel Deaconess Medical Center , National Institutes Of Health , Harvard Medical School , American Diabetes Association , Us Army Medical Research , Preto Medical School , Professor Of Anesthesia At Harvard Medical School , Paulo Research Foundation ,

Lab-made killer T cell attacks cells that cause diabetes

The work could lead to new immunotherapy treatments.
The immune system fights bacteria, viruses, and other pathogens by utilizing several types of T cells, all of which have receptors that are specific to particular antigens. On killer T cells, the receptor works in concert with three signaling modules and a coreceptor to destroy the infected cell.
“When we saw that the 5MCAR T cells completely eliminated the harmful T cells that invaded the pancreas, we were blown away.”
The researchers copied the evolutionary design to engineer a five-module chimeric antigen receptor, or 5MCAR, T cell.
“The 5MCAR was an attempt to figure out if we could build something by biomimicry, using some of evolution’s natural pieces, and redirect T cells to do what we want them to do. We engineered a 5MCAR that would direct killer T cells to target autoimmune T cells that mediate type 1 diabetes,” says Michael Kuhns, an associate professor in the immunobiology department at the ....

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