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Researchers create new polymer to deliver DNA and RNA-based therapies for diseases


Researchers create new polymer to deliver DNA and RNA-based therapies for diseases
University of Minnesota Twin Cities researchers in the Department of Chemistry have created a new polymer to deliver DNA and RNA-based therapies for diseases.
For the first time in the industry, the researchers were able to see exactly how polymers interact with human cells when delivering medicines into the body. This discovery opens the door for more widespread use of polymers in applications like gene therapy and vaccine development.
The research is published in the
Proceedings of the National Academy of Sciences (
PNAS), a peer-reviewed multidisciplinary scientific journal. ....

Renee Frontiera , Theresa Reineke , Emily Henderson , Department Of Chemistry , Proceedings Of The National Academy Sciences , University Of Minnesota Twin Cities , University Of Minnesota , Mcknight University Professor , Minnesota Twin Cities , National Academy , Chemistry Professor , Distinguished Mcknight University , தெரேசா றேணேக்கே , எமிலி ஹென்டர்சன் , துறை ஆஃப் வேதியியல் , பல்கலைக்கழகம் ஆஃப் மினசோட்டா இரட்டை நகரங்கள் , பல்கலைக்கழகம் ஆஃப் மினசோட்டா , மக்நைட் பல்கலைக்கழகம் ப்ரொஃபெஸர் , மினசோட்டா இரட்டை நகரங்கள் , தேசிய கலைக்கழகம் , வேதியியல் ப்ரொஃபெஸர் , புகழ்பெற்ற மக்நைட் பல்கலைக்கழகம் ,

Researchers discover new way to deliver DNA-based therapies for diseases


Researchers discover new way to deliver DNA-based therapies for diseases
Polymers could be used to create less expensive gene therapies or vaccines for diseases
Reineke Group and Frontiera Group, University of Minnesota
The above image shows cells illuminated by quinine (fluorescent blue) and green fluorescent protein. This allows the U of M researchers to for the first time observe how polymers interact with human cells when delivering medicines. The discovery could be used in advancing DNA and RNA-based treatments such as gene therapy and vaccines.
Newswise MINNEAPOLIS / ST. PAUL (12/18/2020) – University of Minnesota Twin Cities researchers in the Department of Chemistry have created a new polymer to deliver DNA and RNA-based therapies for diseases. For the first time in the industry, the researchers were able to see exactly how polymers interact with human cells when delivering medicines into the body. This discovery opens the door for more widespread use ....

Craig Van Bruggen , Renee Frontiera , David Punihaole , Theresa Reineke , Andrew Schmitz , Allison Keith , University Of Minnesota Twin Cities , National Institutes Of Health , College Of Science , National Science Foundation , Mcknight University Professor , Department Of Chemistry , Proceedings Of The National Academy Sciences , University Of Minnesota Medical School , Minnesota Twin Cities , National Academy , Distinguished Mcknight University , Minnesota Medical School , Jakub Tolar , National Institutes , கிரேக் வேன் ப்ருகுஜன் , தெரேசா றேணேக்கே , ஆண்ட்ரூ ஸ்கிமிட்ஸ் , அல்லிசன் கேய்ட் , பல்கலைக்கழகம் ஆஃப் மினசோட்டா இரட்டை நகரங்கள் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் ,

Research brief: Researchers discover new way to deliver DNA-based therapies for diseases


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University of Minnesota Twin Cities researchers in the Department of Chemistry have created a new polymer to deliver DNA and RNA-based therapies for diseases. For the first time in the industry, the researchers were able to see exactly how polymers interact with human cells when delivering medicines into the body. This discovery opens the door for more widespread use of polymers in applications like gene therapy and vaccine development.
The research is published in the
Proceedings of the National Academy of Sciences (
PNAS), a peer-reviewed multidisciplinary scientific journal.
Gene therapy involves altering the genes inside the body s cells to treat or cure diseases. It requires a carrier that packages the DNA to deliver it into the cell oftentimes, a virus is used as a carrier. Packaging of nucleic acids is also used in vaccines, such as the recently developed messenger RNA (mRNA) COVID-19 vaccine, which is enclosed in a lipid. ....

Craig Van Bruggen , Renee Frontiera , David Punihaole , Theresa Reineke , Andrew Schmitz , Allison Keith , University Of Minnesota Twin Cities , National Institutes Of Health , College Of Science , National Science Foundation , Mcknight University Professor , Department Of Chemistry , Proceedings Of The National Academy Sciences , University Of Minnesota Medical School , Minnesota Twin Cities , National Academy , Distinguished Mcknight University , Minnesota Medical School , Jakub Tolar , National Institutes , கிரேக் வேன் ப்ருகுஜன் , தெரேசா றேணேக்கே , ஆண்ட்ரூ ஸ்கிமிட்ஸ் , அல்லிசன் கேய்ட் , பல்கலைக்கழகம் ஆஃப் மினசோட்டா இரட்டை நகரங்கள் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் ,