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Frontiers | Spatial Distribution and Evolution of Ancient Settlements From the Neolithic to the Bronze Age in Dalian Area, China

ArcGIS software was used to analyze the spatial distribution of Mid Holocene (i.e., 6.7-3.1 ka BP) human settlements and sites in the Dalian area. Their evolution was studied in depth alongside the Mid Holocene environmental background known to have existed. The results showed that: ① The number of ancient settlements in the Dalian area increased during this period. Most sites during the three periods studied were to be found 0 to 50 m above sea level (asl), with a significant increase in the number of sites located > 50 m asl during the Bronze Age. In terms of gradient of slope, all settlements were concentrated on coastal plains or in low-altitude, hilly areas on relatively gentle slopes ranging between 0 and 6 °. Settlements from each period faced in all directions, and were mainly located in river valleys or low-altitude mountain valleys with low terrains.② The proximity of ancient settlements to river courses during the Mid Holocene evolved, with Mid and Late Neolithic ....

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Frontiers | A Polygenic Score for Type 2 Diabetes Improves Risk Stratification Beyond Current Clinical Screening Factors in an Ancestrally Diverse Sample

A substantial proportion of the adult US population with type 2 diabetes (T2D) are undiagnosed, calling into question the comprehensiveness of current screening practices, which primarily rely on age, family history, and body mass index (BMI). We hypothesized that a polygenic score (PGS) may serve as a complementary tool to identify high-risk individuals. The T2D PGS maintained predictive utility after adjusting for family history and combining genetics with family history led to even more improved disease risk prediction. We observed that the PGS was meaningfully related to age of onset with implications for screening practices: there was a linear and statistically significant relationship between the PGS and T2D onset (-1.3 years per standard deviation of the PGS). Evaluation of U.S. Preventive Task Force and a simplified version of American Diabetes Association screening guidelines showed that addition of a screening criterion for those above the 90th percentile of the PGS provided ....

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FDP punktet als Gegenentwurf zu grünem Verzicht

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