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Research finds association between genetic changes in head-neck cancer, immunotherapy resistance


Research finds association between genetic changes in head-neck cancer, immunotherapy resistance
ANI |
Updated: May 02, 2021 22:10 IST
Washington [US], May 2 (ANI): A multi-institutional study, drove by the Proceedings of the National Academy of Sciences journal, distinguished both the hereditary abnormalities that drive pre-cancer cells that lead to an intrusive kind of head and neckcancer and patients who are liable to react to immunotherapy to the least extent.
Through a series of surprises, we followed clues that focused more and more tightly on specific genetic imbalances and their role in the effects of specific immune components in tumour development, said co-principal investigator Webster Cavenee, PhD, Distinguished Professor Emeritus at the University of California San Diego School of Medicine. ....

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Researchers identify genetic abnormalities that drive invasiveness in head and neck cancer


Researchers identify genetic abnormalities that drive invasiveness in head and neck cancer
A multi-institutional team of researchers has identified both the genetic abnormalities that drive pre-cancer cells into becoming an invasive type of head and neck cancer and patients who are least likely to respond to immunotherapy.
Through a series of surprises, we followed clues that focused more and more tightly on specific genetic imbalances and their role in the effects of specific immune components in tumor development.
Webster Cavenee, PhD, Co-Principal Investigator, Distinguished Professor Emeritus, University of California San Diego School of Medicine
The genetic abnormalities we identified drive changes in the immune cell composition of the tumors that, in turn, dictates responsiveness to standard of care immune checkpoint inhibitors. ....

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