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When and how immune cells form 'memories' of pathogen encounters and respond upon reinfection

When and how immune cells form 'memories' of pathogen encounters and respond upon reinfection
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University Of Washington , United States , Rajesh Valanparambil , Kathleen Abadie , Armita Nourmohammad , Junyue Cao , Telisa Clark , Obinna Ukogu , Jay Shendure , Keuh Lab University Of Washington , Uw School Of Medicine , College Of Engineering , School Of Medicine , Rafi Ahmed At Emory University , Keuh Lab , National Science Foundation , Hoa Yuan Keuh , Hao Yuan Kueh , Hoa Keuh , Rafi Ahmed , Emory University ,

When and how immune cells decide to form path

<p>Unexpected findings have emerged about how and when certain infection-killing white blood cells decide to form memories about their encounters with a pathogen.&nbsp;</p>

<p>These cells can turn themselves into durable memory cells that can survive a long time after an&nbsp;initial infection is cleared. They are&nbsp;prepared to&nbsp;recognize and eliminate future intrusions by the same kind of pathogen.</p>

<p>That is one reason people are resistant to some infectious diseases after exposure to or recovery from the illness. Vaccinations also work this way, by teaching the immune system to spot and attack dangerous viruses, parasites or bacteria.</p>

<p>Researchers have discovered a reversible switch in cytotoxic T lymphocytes, a type of immune white blood cell that directly destroys infected cells. The switch enables cells that have decided to become short-lived effector cells with potent cell-killing abi ....

Obinna Ukogu , Armita Nourmohammad , Kathleen Abadie , Jay Shendure , Rajesh Valanparambil , Telisa Clark , Junyue Cao , National Science Foundation , Method Of Research , Howard Hughes Medical Institute , National Human Genome Research , Uw School Of Medicine , National Science Foundation Research Fellowships , Rockefeller University , School Of Medicine , Rafi Ahmed At Emory University , Department Of Physics , University Of Washington , College Of Engineering , Hao Yuan Kueh , Rafi Ahmed , Emory University , National Institutes , Health National Institute , Biomedical Imaging , Bioengineering Trailblazer Awards ,