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Researchers discover elusive cell type in fish sensory organs


Researchers discover elusive cell type in fish sensory organs
One of the evolutionary disadvantages for mammals, relative to other vertebrates like fish and chickens, is the inability to regenerate sensory hair cells. The inner hair cells in our ears are responsible for transforming sound vibrations and gravitational forces into electrical signals, which we need to detect sound and maintain balance and spatial orientation. Certain insults, such as exposure to noise, antibiotics, or age, cause inner ear hair cells to die off, which leads to hearing loss and vestibular defects, a condition reported by 15% of the US adult population. In addition, the ion composition of the fluid surrounding the hair cells needs to be tightly controlled, otherwise hair cell function is compromised as observed in Ménière s disease. ....

Tatjana Piotrowski , Julia Peloggia , Emily Henderson , Piotrowski Lab , Stowers Institute For Medical Research , Stowers Institute , Medical Research , Hearing Restoration Project , Hearing Health Foundation , Developmental Cell , Graduate School , எமிலி ஹென்டர்சன் , ஸ்டோவர்ஸ் நிறுவனம் க்கு மருத்துவ ஆராய்ச்சி , ஸ்டோவர்ஸ் நிறுவனம் , மருத்துவ ஆராய்ச்சி , கேட்டல் ஆரோக்கியம் அடித்தளம் , வளர்ச்சி செல் , பட்டதாரி பள்ளி ,

Discovery of an elusive cell type in fish sensory organs


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Credit: Piotrowski Lab
KANSAS CITY, MO One of the evolutionary disadvantages for mammals, relative to other vertebrates like fish and chickens, is the inability to regenerate sensory hair cells. The inner hair cells in our ears are responsible for transforming sound vibrations and gravitational forces into electrical signals, which we need to detect sound and maintain balance and spatial orientation. Certain insults, such as exposure to noise, antibiotics, or age, cause inner ear hair cells to die off, which leads to hearing loss and vestibular defects, a condition reported by 15% of the US adult population. In addition, the ion composition of the fluid surrounding the hair cells needs to be tightly controlled, otherwise hair cell function is compromised as observed in Ménière s disease. ....

United States , Tatjana Piotrowski , Jim Stowers , Julia Peloggia , Paloma Meneses Giles , Nathand Lawson , Y Albert Pan , Melainia Mcclain , Piotrowski Lab , Stowers Institute For Medical Research , University Of Massachusetts Medical School , National Institute Of Child Health , Stowers Institute , Medical Research , Hearing Restoration Project , Hearing Health Foundation , Developmental Cell , Graduate School , Massachusetts Medical School , Virginia Tech , National Institute , Child Health , Human Development , National Institutes , Investigator Tatjana Piotrowski , American Century Investments ,