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Study uncovers critical roles for USP1 in Ewing sarcoma

A new research paper was published in Genes & Cancer on February 5, 2024, entitled, "Roles of USP1 in Ewing sarcoma." ....

Yuzuru Shiio , Panneerselvam Jayabal , Xiuye Ma , Impact Journals , University Of Texas Health Science Center , Texas Health Science Center , Ewing Sarcoma ,

Dying Mom Dedicates Her Last Song To Son, TikTok Makes It Go Viral

A singer with cancer wrote a final tune for her 7-year-old son and people on TikTok made it go viral as her dying wish. ....

Cat Janice , Dance Outta My Head , Inal Track , Dance Outta My Head ,

Pazopanib activity confirmed in EWSR1-NFATC2 bone sarcoma

A new case report was published in Oncoscience (Volume 10) on September 20, 2023, entitled, "Activity of pazopanib in EWSR1-NFATC2 translocation-associated bone sarcoma." ....

United States , Huberth Chuang , Mariaa Zarzour , Kalevi Kairemo , Vivek Subbiah , Sarah Cannon Research Institute , Impact Journals , University Of Texas Md Anderson Cancer Center , Cancer Center , Kinase Inhibitor , Renal Cell Carcinoma , Soft Tissue Sarcoma ,

"Development of an automated treatment planning approach for lattice ra" by Mathieu Gaudreault, David Chang et al.

Background: Lattice radiation therapy (LRT) alternates regions of high and low doses within the target. The heterogeneous dose distribution is delivered to a geometrical structure of vertices segmented inside the tumor. LRT is typically used to treat patients with large tumor volumes with cytoreduction intent. Due to the geometric complexity of the target volume and the required dose distribution, LRT treatment planning demands additional resources, which may limit clinical integration. Purpose: We introduce a fully automated method to (1) generate an ordered lattice of vertices with various sizes and center-to-center distances and (2) perform dose optimization and calculation. We aim to report the dosimetry associated with these lattices to help clinical decision-making. Methods: Sarcoma cancer patients with tumor volume between 100 cm3 and 1500 cm3 who received radiotherapy treatment between 2010 and 2018 at our institution were considered for inclusion. Automated segmentation and do ....

United States , Varian Medical Systems , Palo Alto , Plan Optimization ,