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22 research highlights from the past year

MD Anderson researchers are driven by a shared goal to end cancer. Here are 22 of their most impactful accomplishments from this past year. ....

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Some Recurrent Disease Following Ductal Carcinoma In Situ Unrelated to Initial Lesions, Study Finds

The finding contrasts with the previous thought that most later recurrences arise from the original ductal carcinoma in situ lesion. ....

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Genomic analysis provides a deeper understanding of DCIS biology

A new study led by the global Cancer Grand Challenges PRECISION team, including researchers from The University of Texas MD Anderson Cancer Center, shifts the long-held belief that all invasive breast cancers following ductal carcinoma in situ (DCIS) arise from the original DCIS lesion. ....

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Genetic study offers new insights into DCIS biology, progression

Genetic study offers new insights into DCIS biology, progression
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New computational tool reliably differentiates between cancer and normal cells from single-cell RNA-sequencing data

Credit: MD Anderson Cancer Center
HOUSTON In an effort to address a major challenge when analyzing large single-cell RNA-sequencing datasets, researchers from The University of Texas MD Anderson Cancer Center have developed a new computational technique to accurately differentiate between data from cancer cells and the variety of normal cells found within tumor samples. The work was published today in
Nature Biotechnology.
The new tool, dubbed CopyKAT (copy number karyotyping of aneuploid tumors), allows researchers to more easily examine the complex data obtained from large single-cell RNA-sequencing experiments, which deliver gene expression data from many thousands of individual cells.
CopyKAT uses that gene expression data to look for aneuploidy, or the presence of abnormal chromosome numbers, which is common in most cancers, said study senior author Nicholas Navin, Ph.D., associate professor of Genetics and Bioinformatics & Computational Biology. The tool ....

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