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Breakthrough in Parkinson's research: Scientists identify protein synthesis pathway as culprit

A so-called pathological protein long associated with Parkinson's disease has been found in a new study to trigger cells to increase protein synthesis, an event that eventually kills the subset of brain cells that die off in this neurodegenerative condition. ....

Senthilkumar Karuppagounder , Jaba Mitra , Tedm Dawson , Aanishaa Jhaldiyal , Rong Chen , Johns Hopkins , Saurav Brahmachari , Hyun Hee Kim , Taekyung Ryu , Javier Redding Ochoa , Juan Troncoso , Yasuyoshi Kimura , Zhao Gu , Department Of Neurology , Johns Hopkins University School Of Medicine , Institute For Cell Engineering , Bumpus Foundation , Johns Hopkins University School , Science Translational , Cell Engineering , Mohammed Repon Khan , Xiling Yin , Sung Ung Kang , Arkinson 39s Disease , Protein Synthesis ,

New findings about key pathological protein i

<p>A so-called pathological protein long associated with Parkinson’s disease has been found in a new study to trigger cells to increase protein synthesis, an event that eventually kills the subset of brain cells that die off in this neurodegenerative condition. Researchers from the Johns Hopkins University School of Medicine who conducted the study say the findings offer potential new targets for treating Parkinson’s disease, which affects about <a href="https://www.ninds.nih.gov/current-research/focus-disorders/parkinsons-disease-research/parkinsons-disease-challenges-progress-and-promise#:~:text=Approximately%20500%2C000%20Americans%20are%20diagnosed,1%20million%20Americans%20have%20PD.">1% of the U.S. population over age 60</a> and has no cure.</p>
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Saurav Brahmachari , Juan Troncoso , Aanishaa Jhaldiyal , Taekyung Ryu , Rong Chen , Zhao Gu , Hyun Hee Kim , Johns Hopkins , Tedm Dawson , Yasuyoshi Kimura , Javier Redding Ochoa , Senthilkumar Karuppagounder , Jaba Mitra , Institute For Cell Engineering , Department Of Neurology , Bumpus Foundation , Johns Hopkins University School Of Medicine , Johns Hopkins University School , Science Translational Medicine , Cell Engineering , Mohammed Repon Khan , Xiling Yin , Sung Ung Kang ,

Research Finds Protein May Predict Mild Cognitive Impairment Years Before Symptoms

Results of a long-term, federally funded study of cognitively healthy adults most with a family history of Alzheimer’s disease have added to evidence that low spinal fluid levels of a protein linked to learning and memory in mice may serve as an ....

United States , Anja Soldan , Paul Worley , Gregory Pontone , Taekyung Ryu , Marilyn Albert , Abhay Moghekar , Corinne Pettigrew , Yuxin Zhu , Mei Fang Xiao , Johns Hopkins University School Of Medicine , National Institutes Of Health , Alzheimer Association , Johns Hopkins Medicine , Johns Hopkins University School , National Institutes ,

Low levels of 'memory strengthening protein' may serve as early predictor of mild cognitive impairment

Results of a long-term, federally funded study of cognitively healthy adults most with a family history of Alzheimer's disease have added to evidence that low spinal fluid levels of a protein linked to learning and memory in mice may serve as an early predictor of mild cognitive impairment (MCI) years before symptoms appear. ....

United States , Abhay Moghekar , Anja Soldan , Corinne Pettigrew , Paul Worley , Taekyung Ryu , Gregory Pontone , Mei Fang Xiao , Marilyn Albert , Yuxin Zhu , Megan Craig , National Institutes Of Health , Alzheimer Association , Johns Hopkins University School Of Medicine , Johns Hopkins Medicine , Johns Hopkins University School , National Institutes , Lzheimer 39s Disease ,

ScienceDaily: Protein measurement in cerebrospinal fluid of cognitively healthy adults predicts early onset of mild cognitive impairment and dementia prior to symptom manifestation.

ScienceDaily: Protein measurement in cerebrospinal fluid of cognitively healthy adults predicts early onset of mild cognitive impairment and dementia prior to symptom manifestation.
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United States , Taekyung Ryu , Paul Worley , Mei Fang Xiao , Anja Soldan , Abhay Moghekar , Yuxin Zhu , Corinne Pettigrew , Marilyn Albert , Gregory Pontone , Alzheimer Association , National Institutes Of Health , Johns Hopkins University School Of Medicine , Johns Hopkins Medicine , Johns Hopkins University School , National Institutes ,