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Largest genetic study of gestational diabetes discovers nine novel genetic regions linked to severe and common pregnancy complication

Researchers investigated the genetic underpinnings of Gestational Diabetes Mellitus (GDM) and its relationship with Type 2 Diabetes (T2D) through a genome-wide association study ((GWAS), identifying distinct and shared genetic factors. ....

Photoroyalty Shutterstock , Coloc Association Visualization , Nature Genetics , Gestational Diabetes Mellitus , Finnish Biobank , Biobank Access Decisions , Ridge Regression Based Efficient , Single Effects , Single Nucleotide Polymorphisms , Estonian Biobank , Ensembl Variant Effect Predictor , Finnish European , Integration Resource , Expression Quantitative Trait Loci , Multi Marker Analysis , Genomic Annotation , Linkage Disequilibrium Score Regression , Tabula Muris , Significant Cross Trait Outliers , Joint York , Gestational Diabetes , Diabetes Mellitus , Type 2 Diabetes ,

Dataset Formed to Study the Functions of Immune Cells

As a central component of the human immune system, mononuclear phagocytes defend the body by absorbing bacteria, viruses, and dead or damaged cells, thus fighting off infections and helping build immunity. Researchers from ITMO University, together w ....

Anastasiia Gainullina , Immunological Genome Project , Gene Expression Omnibus , Tabula Muris , Immgen Open Source , Immgen Phase , Tabula Muris Senis ,

A ligand-receptor interactome platform for discovery of pain mechanisms and therapeutic targets

Science for just $15 USD.
Painful connections
Chronic pain impairs quality of life, is challenging to treat, and accompanies various diseases. Wangzhou
et al. integrated bulk and single-cell RNA sequencing of ligand and receptor gene expression in the dorsal root ganglion (DRG) and various peripheral cell types from humans and mice. Computational analysis of these data enabled the construction of a connectome of potential and cell type–specific interaction points between sensory nerves and innervated tissues. With validation in a mouse model of mechanical pain, their findings suggest that blocking heparin-binding epidermal growth factor (HBEGF) signaling may be a common and effective way to alleviate chronic pain in arthritis, colitis, and pancreatic cancer. The resource and the approach, in general, may be used to predict mechanisms of cell-cell communication between various tissues and cell types. ....

United States , Stoelting Co , Human Genome Organization , Allen Institute , University Of Texas At Dallas , National Institutes Of Health , Hamilton Co , Metafluor Fluorescence Ratio Imaging Software , Tabula Muris , Dallas Institutional Animal Care , Use Committee , National Institutes , Life Technologies , Metafluor Fluorescence Ratio Imaging , ஒன்றுபட்டது மாநிலங்களில் , மனிதன் மரபணு ஆர்கநைஸேஶந் , ஆலன் நிறுவனம் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் இல் டல்லாஸ் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , ஹாமில்டன் இணை , டல்லாஸ் நிறுவன விலங்கு பராமரிப்பு , பயன்பாடு குழு , தேசிய நிறுவனங்கள் , வாழ்க்கை தொழில்நுட்பங்கள் ,