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CAR-T SEAKER Cells Activate Small Molecule Drugs at Tumor Site

CAR-T cells, engineered to act as cancer drug "micropharmacies," could address challenges with eliminating tumor masses and toxicity.

Charles nicoletteDavid scheinbergNature chemical biologyMemorial sloan kettering cancer centerSloan kettering instituteSynthetic enzyme armedDerek tan

Sloan Kettering Institute Researchers retool CAR T cells to serve as micropharmacies for cancer drugs

Immunotherapies called chimeric antigen receptor (CAR) T cells use genetically engineered versions of a patient’s own immune cells to fight cancer

Davida scheinbergCharles nicoletteNational institutes of healthMolecular pharmacology programChemical biology programMemorial sloan kettering cancer centerSloan kettering instituteSynthetic enzyme armedBiology program chair derek tanNature chemicalExperimental therapeuticsNational institutes

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