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Pan-Genotypic DAA Regimens Safe, Effective for Children, Adolescents with Chronic HCV

Results of the systematic review and meta-analysis support the use of pan-genotypic DAA regimens for the treatment of chronic HCV in adolescents and children ≥ 3 years of age. ....

World Health Organization , Al Qahirah , Giuseppe Indolfi , Anna Meyer Children University , World Journal , Anna Meyer Children , Hepatitisc Virus , Direct Acting Antivirals , Sustained Virological Response ,

Hepatology Month in Review: January 2024

The editorial team’s monthly recap of the top news in hepatology features research emphasizing women’s health in liver disease, a look at some less-recognized health benefits associated with achieving SVR, and promising approaches for preventing and treating hepatic conditions. ....

West Virginia , United States , Tatyana Kushner , National Health , Nutrition Examination Survey , Icahn School Of Medicine At Mount Sinai , Greater Focus , Icahn School , Mount Sinai , Hepatitis C , Sustained Virological Response , Nonalcoholic Fatty Liver Disease , Metabolic Dysfunction Associated Steatotic Liver Disease , Metabolic Dysfunction Associated And Alcohol Related Liver Disease ,

Achieving SVR Reduces Risk of Cardiovascular Events in Patients with HCV

Results highlight the benefit of achieving sustained virological response with DAAs for decreasing patients’ risk of carotid atherosclerosis and peripheral artery disease, especially among those with severe fibrosis. ....

Anca Trifan , World Health Organization , World Journal , Internal Medicine , Lancet Gatroenterology , Hepatitisc Virus , Sustained Virological Response , Carotid Atherosclerosis , Direct Acting Antivirals , Peripheral Artery Disease ,

Artificial Intelligence Model Predicts HCV Patients At Risk of Treatment Failure

The XGBoost machine learning model outperformed other AI and logistic regression models for predicting DAA failure, with an AUROC of 1.000 in the training dataset and 0.803 in the validation dataset. ....

National Sun Yat Sen University , Kao Hsiung , Coalition For Global Hepatitis Elimination Ming , World Health Organization , Global Hepatitis Elimination , Taiwan Association , Extreme Gradient Boosting , Shapley Additive , Hepatitisc Virus , Direct Acting Antivirals , Sustained Virological Response , Artificial Intelligence , Machine Learning ,

Hepatitis C Genotype, Cirrhosis, Gender May Impact Effectiveness of DAA Therapy

Although the overall response rate among the cohort was 96.4%, this figure dropped as low as 66.7% when accounting for male gender, GT3 infection, cirrhosis, obesity, and non-response to previous therapy. ....

Sofosbuvir Velpatasvir , Robert Flisiak , University Of Bialystok , University Of Bialystok Robert Flisiak , World Health Organization , Medical University , March Intern , Hepatitis C , Direct Acting Antiviral , Sustained Virological Response ,