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The need for validation of prediction models and assessment of heterogeneity in performance bmj.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from bmj.com Daily Mail and Mail on Sunday newspapers.
There are abundant clinical data recorded in general practice electronic health records (EHR) which are suitable for longitudinal analysis to inform clinical care. This thesis proposes a novel research approach which has potential to deliver clinically relevant outcomes using real-world data and at the same time provide individual general practices with important feedback. This thesis includes a literature review which demonstrates the utility of longitudinal research, specifically survival analysis using primary care EHR data. The growing trend of this approach reflects its usefulness in general practice research. ....
Purpose: Young learner drivers commonly must record substantial supervised practice driving before independent licensure. Supervisory driver requirements can be limited or highly regulated, yet research is lacking on the effectiveness of different approaches. The current objective was to explore whether young drivers who were mostly supervised by someone who they perceived had traffic offences versus no offences had different crash records over a period of 13 years postlicensing. Methods: DRIVE is an Australian prospective cohort study of more than 20,000 drivers who were aged 17–24 years and newly licensed during 2003–2004. They completed detailed baseline questionnaires, including whether the person they identified as supervising their learner driving the most had perceived traffic offences in the past 12 months. Responses were linked to their state crash, hospitalization, and death records to 2016. A parametric survival model was created to calculate hazard ratios of time to cra ....