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"Promiscuous evolution of Group A Streptococcal M and M-like proteins" by Hannah R. Frost, Julien Guglielmini et al.

Group A Streptococcus (GAS) M and M-like proteins are essential virulence factors and represent the primary epidemiological marker of this pathogen. Protein sequences encoding 1054 M, Mrp and Enn proteins, from 1668 GAS genomes, were analysed by SplitsTree4, partitioning around medoids and co-occurrence. The splits network and groups-based analysis of all M and M-like proteins revealed four large protein groupings, with multiple evolutionary histories as represented by multiple edges for most splits, leading to ‘M-family-groups’ (FG) of protein sequences: FG I, Mrp; FG II, M protein and Protein H; FG III, Enn; and FG IV, M protein. M and Enn proteins formed two groups with nine sub-groups and Mrp proteins formed four groups with ten sub-groups. Discrete co-occurrence of M and M-like proteins were identified suggesting that while dynamic, evolution may be constrained by a combination of functional and virulence attributes. At a granular level, four distinct family-groups of M, Enn a ....

Groupa Streptococcus , Mga Regular , Streptococcus Pyogenes , Surface Protein ,

Transcripts for MSNBC Stephanie Ruhle Reports 20210812 13:02:00

Johnson&johnson remain very good at doing that. you can t expect this kind of vaccine also to be highly effective against highly asymptomatic, that s good for the rotovirus or flu vaccine. you can get control of this infection by just having protection against moderate severe critical disease. so i think when people are holding up the bar of trying to get protection against asymptomatic or mildly symptomatic, that s too high a bar. i think we are scaring ours unnecessarily. is the answer at some point we will need booster shots sooner than later? similar to flu shot? i get one every fall? flu is a moving target. the surface protein of flu is always mutating so that you need a yearly vaccine. that s not going to be this vaccine. what you want is you want a good immune logical memory, i suspect you will need a booster when you ....

Flu Vaccine , Point Of View , Booster Shots , Surface Protein , Flu Shot ,