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Frontiers | Low mutation rate of spontaneous mutants enables detection of causative genes by comparing whole genome sequences

Frontiers | Low mutation rate of spontaneous mutants enables detection of causative genes by comparing whole genome sequences
frontiersin.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from frontiersin.org Daily Mail and Mail on Sunday newspapers.

Toyama Nougi , Ginbouzu Terada , Honzou Zuhu , Clustal Omega , Aizu Nousho , Ito Shoten , Ricexpro Sato , Pavir Ib , Snpeff Cingolani , Development Program For Agriculture , Technology Research Advancement Institution , Cabinet Office , Moonshot Research , Priority Research , Library Prep Reagent Set Biolabs , Japan Society For The Promotion Of Science , Fukushima University , Kyushu University , Bj Springer International Publishing , Illumina Co Ltd , Scientific Research , Plant Mini Kit , Prep Reagent Set , Illumina Hiseq , Genebank Project , New England Biolabs ,

Biobank-wide association scan identifies risk factors for late-onset Alzheimer's disease and endophenotypes

Biobank-wide association scan identifies risk factors for late-onset Alzheimer's disease and endophenotypes
elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.

United Kingdom , United States , Benjamin Neale , Alzheimer Disease Genetics Consortium , College Or University , Association Discovery , International Genomics Of Alzheimer Project , Genetic Epidemiology Research On Adult Health , Biobank Wide Association Discovery , Risk Scores , Supplementary Figure , Genetic Epidemiology Research , Adult Health , Supplementary Table , Supplementary Figures , International Genomics , Disease Genetics Consortium , Executive Prominent Alzheimer , Wisconsin Registry ,

Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens

Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens
elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.

Buenos Aires , Distrito Federal , Pkas Mohanty , Eleni Polatoglou , Trypanosoma Bachmaier , Thomas Carell , Ricardo Biondi , Pkas Canaves , Michaela Smolle , Jena Bioscience , Ligprep Schr , Ralph Heermann , Pkacs Jena Bioscience , Interchim Uptisphere , Transfected Mitat , Life Sciences Munich , Gene Center , Ge Healthcare , Gibbs Free Energy , Omicron Biochemicals Inc , Bb Hydrogen , Protein Data Bank , Structure Activity Relationship , Supplementary Table , Supplementary Movie , Andreas Anger ,

Frontiers | Assessing the activity of mud volcanism using boron isotope ratios in pore water from surface sediments of mud volcanoes off Tanegashima (SW Japan)

Frontiers | Assessing the activity of mud volcanism using boron isotope ratios in pore water from surface sediments of mud volcanoes off Tanegashima (SW Japan)
frontiersin.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from frontiersin.org Daily Mail and Mail on Sunday newspapers.

United States , Dead Sea , Israel General , Japan Sea , Oceans General , Hsin Wei , Kao Hsiung , Philippine Sea , Japan Trench , Japan General , Nansei Shoto Trench , City Of , United Kingdom , Costa Rica , Sea Vengosh , Orlando Vaselli , Karolyn Rijeka , Tanegashima Ujii , Geochimica Cosmochimica Acta , Pacific Ocean , Marcelo Ketzer , Acta Geologica Taiwanica , Kumage Group , Research Projects Interdisciplinary , Ocean Drilling Program Site , Eocene Kumage Group ,

Complete human day 14 post-implantation embryo models from naïve ES cells

The ability to study human post-implantation development remains limited due to ethical and technical challenges associated with intrauterine development after implantation1. Embryo-like models with spatially organized morphogenesis of all defining embryonic and extra-embryonic tissues of the post-implantation human conceptus (i.e., embryonic disk, bilaminar disk, yolk- and chorionic sacs, surrounding trophoblasts) remain lacking2. Mouse naïve embryonic stem cells (ESCs) have recently been shown to give rise to embryonic and extra-embryonic stem cells capable of self-assembling into post-gastrulation mouse Structured Stem cell-based Embryo Models with spatially organized morphogenesis (SEMs)3. Here, we extend these findings to humans, while using only genetically unmodified human naïve ESCs (in HENSM conditions)4. Such human fully integrated SEMs recapitulate the organization of nearly all known lineages and compartments of post-implantation human embryos including epiblast, ....

Supplementary Figures , Supplementary Introduction , Supplementary Discussion , Extended Data ,