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The effect of changing screening practices and demographics on the incidence of gestational diabetes in British Columbia, 2005–2019

Background: Rates of gestational diabetes are reported to be increasing in many jurisdictions, but the reasons for this are poorly understood. We sought to evaluate the relative contribution of screening practices for gestational diabetes (including completion and methods of screening) and population characteristics to risk of gestational diabetes in British Columbia, Canada, from 2005 to 2019.

Methods: We used a population-based cohort from a provincial registry of perinatal data, linked to laboratory billing records. We used data on screening completion, screening method (1-step 75-g glucose test or 2-step approach of 50-g glucose screening test, followed by a diagnostic test for patients who screen positive) and demographic risk factors. We modelled predicted annual risk for gestational diabetes, sequentially adjusted for screening completion, screening method and risk factors.

Results: We included 551 457 pregnancies in the study cohort. The incidence of gestational d ....

United States , United Kingdom , Jennifer Hutcheon , Elizabeth Nethery , International Association Of Diabetes , International Classification Of Diseases , Bc Medical Services Plan , American College Of Obstetricians , Canada Research , Health Canada , Health Problems , University Of British Columbia Research Ethics Board , Perinatal Population Health , British Columbia , International Association , Pregnancy Study Groups , Services Plan , Population Data , International Classification , Related Health Problems , Data Registry , Prenatal Care Utilization Index , British Columbia Research Ethics Board , Supplemental Table , Supplemental Figures , Supplemental Figure ,

Complement C3a and C3a Receptor Activation Mediates Podocyte Injuries in the Mechanism of Primary Membranous Nephropathy

Complement C3a and C3a Receptor Activation Mediates Podocyte Injuries in the Mechanism of Primary Membranous Nephropathy
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Pathologic Data , Supplemental Table , Supplemental Figure , Supplemental Figures ,