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January 25, 2021 Even in asymptomatic patients with aortic stenosis (AS) and minimal signs of cardiac damage, early treatment with surgery provides a long-term survival benefit over conservative management, a new analysis of the RECOVERY trial shows. Researchers assessing the prognostic value of a disease classification tool which relies on the degree of damage to stage AS found much lower rates of CV or all-cause death at 8 years for patients in the lower stages compared with higher stages. But surgery across all disease categories still offered benefits over conservative management, they said. “Because the risk-benefit ratio of early elective AVR over conservative management in asymptomatic AS may differ according to stages of cardiac damage, further prospective studies will be necessary to facilitate the identification of patients that may benefit from early intervention,” write Sung-Ji Park, MD, PhD (Asan Medical Center, Seoul, Korea), and colleagues in a rese ....