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Purpose: The study aimed to ascertain the potential effects of chronic kidney disease (CKD) on substance P concentration in the tear film of people with type 2 diabetes. Methods: Participants were classified into two groups: type 2 diabetes with concurrent chronic kidney disease (T2DM–CKD (n = 25)) and type 2 diabetes without chronic kidney disease (T2DM–no CKD (n = 25)). Ocular surface discomfort assessment, flush tear collection, in-vivo corneal confocal microscopy, and peripheral neuropathy assessment were conducted. Enzyme-linked immunosorbent assays were utilized to ascertain the levels of tear film substance P in collected flush tears. Correlation analysis, hierarchical multiple linear regression analysis, and t-tests or Mann–Whitney U tests were used in the analysis of data for two-group comparisons. Results: There was no substantial difference between the T2DM–CKD and T2DM–no CKD groups for tear film substance P concentration (4.4 (0.2–50.4) and 5.9 (0.2–47.2) ng/ ....
Discussing all of this. everybody knows that the opportunity expires at the end of the month. it is better than the status quo by far and i think that s an argument we all come full makin making. reporter: what concerns you about time and terms of getting everything done you want to get done? i think we ll be fine. harris: meanwhile, lamar alexander and patty murray were working on a deal when negotiations broke down. democrats are blaming republicans, i m sure it s going both ways, saying they failed to push through their new bill. chuck schumer with this statement on it. this is not about substance p or we give them any of the things they asked for, the republic and leadership is so eager to pass graham-cassidy, that they re scuttling a balance of bipartisan negotiations. colonel, what do you think? michael: i was just down in jacksonville where i m from and they had horrific flooding and people down there are so fed up. ....