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#VisualAbstract: Iptacopan improves hematologic and clinical outcomes in paroxysmal nocturnal hemoglobinuria

1. In two clinical trials, iptacopan in patients with paroxysmal nocturnal hemoglobinuria (PNH) improved hemoglobin levels compared to anti-C5-treated patients and those without complement inhibitors. 2. Patients who received iptacopan generally exhibited improved secondary outcomes, including less fatigue, reduced reticulocyte and bilirubin levels, and decreased breakthrough hemolysis. Evidence Rating Level: 1 (Excellent) Study Rundown: PNH is a ....

Paroxysmal Nocturnal Hemoglobinuria ,

#VisualAbstract: Aspirin reduces hepatic fat quantity in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) without Cirrhosis

Click here to read this study in JAMA. ©2024 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc. ....

Minute Medicine Inc , Liver Disease , Metabolic Dysfunction Associated Steatotic Liver Disease , Metabolic Dysfunction Associated Steatotic Liver Disease Masld ,

#VisualAbstract: Preoperative breast MRI may reduce need for adjuvant radiotherapy for women with unifocal breast cancer

1. There were similar rates of ipsilateral invasive recurrence among the postoperative adjuvant radiotherapy group (group 1) and non-radiotherapy group (group 2). 2. 2% of patients in the total cohort underwent mastectomy and all of them were in the non-radiotherapy group. Evidence Rating Level: 1 (Excellent) Study Rundown: Adjuvant breast radiotherapy is a common practice in early ....

Minute Medicine Inc , Rating Level , Breast Conserving Surgery , Early Breast , Between May , Breast Cancer , Breast Surgery ,

#VisualAbstract: Cervical intraepithelial neoplasia grade 2 and risk of preterm birth

1. For women with cervical intraepithelial neoplasia grade 2 (CIN2), the risk of preterm birth was similar for those who underwent active surveillance compared to immediate loop electrosurgical excision procedure (LEEP) 2. The risk of preterm birth was greater for those who underwent delayed LEEP compared to immediate LEEP. Evidence Rating Level: 2 (Good) Cervical intraepithelial ....

Cervical Cancer ,

#VisualAbstract: Omalizumab is superior to placebo in reducing the reaction threshold for patients with multiple food allergies

Click here to read this study in NEJM. ©2024 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute ....

Minute Medicine Inc , Food Allergies , Peanut Allergy ,