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Andexanet yields better control of hematoma expansion than usual care, finds study

For patients who had taken factor Xa inhibitors within 15 hours before having an acute intracerebral hemorrhage, andexanet alfa, which reverses the effects of factor Xa inhibitors, results in better control of hematoma expansion than usual care, according to a study published in the New England Journal of Medicine. ....

Stuartj Connolly , Wades Smith , Mcmaster University , New England Journal , Factor Xa Inhibitor , Associated Acute Intracerebral Hemorrhage , Reversing Oral Anticoagulation , Intracerebral Hemorrhage ,

Key Takeaways From ANNEXA-I Study

Dr Connolly highlights the cautious patient selection and the significance of reducing hematoma expansion for improved outcomes in cases of intracerebral hemorrhage (ICH) associated with the use of a reversal agent for factor Xa inhibitors. ....

Stuartj Connolly , Hematoma Expansion , Intracerebral Hemorrhage , Direct Oral Anticoagulant , Annexai Study , Hemostatic Efficacy , Factorx Inhibitor , Risk Factors , Baseline Nih , Baseline Nih Score , Andexanet Alfa , 4 Factor Prothrombin Complex Concentrate ,

Top in cardiology: Iron injection for heart failure; ANNEXA phase IV trial stopped

The FDA has approved the first-ever IV iron replacement therapy to improve exercise capacity in adults with heart failure. The IV ferric carboxymaltose injection (Injectafer; Daiichi Sankyo Inc./American Regent) was approved for patients with New York Heart Association class II/III heart failure, which is defined as a slight or marked limitation of physical activity due to fatigue, palpitation ....

United States , Stuartj Connolly , York Heart Association , Daiichi Sankyo Inc American Regent , Population Health Research Institute , Mcmaster University , Ge Healthcare , Healio Coverage , Daiichi Sankyo Inc , American Regent , New York Heart Association ,