Post-translational modifications (PTMs) provide a rapid mechanism that enables protein phenotypic diversity so that proteins can react to external and internal disturbances and regulate cellular activity. This Biotech Brief discusses tools and methods that are employed in detecting these sub-stoichiometric and elusive protein modifiers, including mass spectrometry, antibody, artificial intelligence, ubiquitin-clipping, and specific uncaging-assisted biotinylation-based approaches. The article also discusses challenges in detecting PTMs, such as the development of PTM antibodies with high specificity and binding affinity.
Bangladeshi student wins prestigious award in computational biology competition: Raj Shekhor Roy, a Bangladeshi PhD student under the supervision of Dr. Jianlin Cheng, has garnered exceptional success at the prestigious Critical Assessment of Structure Prediction (CASP) competition in the Estimation of Model Accuracy (EMA) category, making him one of the few Bangladeshis to
AlphaFold AI Uncovers New 3D Proteins with Open Data miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.
AlphaFold's AI protein-structure predictions have limits sciencenews.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencenews.org Daily Mail and Mail on Sunday newspapers.