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"Constrained optimization for stratified treatment rules in reducing ho" by Haiyan Yu, Ching Chi Yang et al.

Diabetic patients can receive multiple/different treatments. However, there is no universal solution for all patients, i.e., one prescription can treat some patients, but it may not be effective for others. Therefore, if we can stratify those patients into several sub-classes, the patients in each sub-class can receive the optimal treatment. There are two main challenges: (1) counterfactual inference when a patient can only take one treatment at a time, i.e., a long time is required to collect an adequate amount of patient data for analysis; (2) the confounding effects of covariates on the treatment. To address these challenges, we propose a method entitled constrained optimization for stratified treatment rules (COSTAR). The proposition is to view the realized treatment outcome as observable but the unrealized as missing values. Thus, the problem becomes finding the optimal treatment with missing outcomes and covariate balance constraints. Through the method COSTAR, the experiment res ....

Constrained Optimization , Ovariate Balancing , Data Science , Missing Data , Stratified Treatment ,

Biomarker-Guided Steroid Therapy Shown Safe for COPD

Treatment failure rates not significantly lower for eosinophil-guided prescribing of corticosteroids compared with empiric prescribing. ....

United Kingdom , City Of , Sohail Ansari , Mona Bafadhel , Dave Singh , King College London , University Of Oxford , European Respiratory Society Congress , University Of Manchester , National Institute For Health , European Respiratory Society , Care Research , College London , Stratified Treatment , Reduce Risk , Good Thing , South Essex , National Institute , Lung United Kingdom , Respiratory Society Congress , Presented September , Chronic Obstructive Pulmonary Disease Copd , Chronic Obstructive Pulmonary Disease , Chronic Obstructive Lung Disease , Primary Care , Iological Marker ,

Echocardiography Follow-Up Duration in Kawasaki Disease Patients

Get to know about the optimal duration of echocardiographic follow-up in patients with Kawasaki disease who haven't had a cardiac aneurysm before. ....

Prospective Observational Study , Stratified Treatment , Immunoglobulin Plus Steroid Efficacy ,