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Estimands can be used in studies of healthcare interventions to clarify the interpretation of treatment effects. The addendum to the ICH E9 harmonised guideline on statistical principles for clinical trials (ICH E9(R1)) describes a framework for using estimands as part of a study. This paper provides an overview of the estimands framework, as outlined in the addendum, with the aim of explaining why estimands are beneficial; clarifying the terminology being used; and providing practical guidance on using estimands to decide the appropriate study design, data collection, and estimation methods. This article illustrates how to use the estimands framework by applying it to an ongoing trial in emergency bowel surgery. Estimands can be a useful way of clarifying the exact research question being evaluated in a study, both to avoid misinterpretation and to ensure that study methods are aligned to the overall study objectives. Research studies are often used to answer questions about the effe

United kingdomT ai peiSouth koreaRepublic of koreaSuzie croJoanna hindleyBrennanc kahanMark edwardsTimp morrisGilead sciencesUnited kingdom medical research councilNational institute for healthCare researchBayer healthcare pharmaceuticalsNational research councilTrials methodology research partnership