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Biodegradable, non-ionic polymeric nanovesicles efficiently encapsulate and deliver siRNA

Small interfering RNAs, or siRNAs, hold promise to treat tumors, through their ability to specifically knock down oncogenes that promote tumor growth, without the toxicity that accompanies chemotherapy. However, the siRNAs need a delivery vehicle to protect them from degradation and clearance on their journey through the bloodstream to the cancer tumor. ....

United States , University Of Alabama At Birmingham , Oak Ridge , Veronika Kozlovskaya , Jun Zhang , Yiming Yang , Chuan Xing , Teddy Yang , Zhuo Zhang , Eugenia Kharlampieva , Emily Henderson , Steve Zaharias , Maksim Dolmat , Jasonm Warram , Shuo Qian , Southeast Cancer Foundation , Breast Cancer Research Foundation Of Alabama , National Science Foundation Division Of Materials Research , Department Of Chemistry , Oak Ridge National Laboratory , Department Of Otolaryngology , College Of Arts , Department Of Radiation Oncology , Marnixe Heersink School Of Medicine , Oneal Comprehensive Cancer Center , Radiation Oncology ,

Polymersomes efficiently deliver siRNA to treat breast cancers in preclinical model

Polymersomes efficiently deliver siRNA to treat breast cancers in preclinical model
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University Of Alabama At Birmingham , United States , Oak Ridge , Veronika Kozlovskaya , Jun Zhang , Yiming Yang , Chuan Xing , Teddy Yang , Zhuo Zhang , Eugenia Kharlampieva , Steve Zaharias , Maksim Dolmat , Jasonm Warram , Shuo Qian , Southeast Cancer Foundation , Breast Cancer Research Foundation Of Alabama , National Science Foundation Division Of Materials Research , Department Of Chemistry , Oak Ridge National Laboratory , Department Of Otolaryngology , College Of Arts , Department Of Radiation Oncology , Marnixe Heersink School Of Medicine , Oneal Comprehensive Cancer Center , Radiation Oncology , Cancer Foundation Endowed Chair ,