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Advanced Monitoring and Control

The pathway to continuous processing. Entry of advanced PAT into continuous processing might depend on identifying unit operations or processes that are accessible to this type of approach, or which are in the greatest need. Downstream unit operations such as membrane filtration and chromatography are less complex than upstream unit operations and also have fewer variables to control. ....

City Of , United Kingdom , Alexander Armstrong , Stephen Goldrick , Kieran Horry , University College ,

Advanced Sensing and Controls

A U.K. group has outlined their vision for downstream process analytic technology and quality by design within the context of batch vs. continuous chromatography. The researchers note that limitations of conventional industrial fractionation control strategies (e.g., in-line UV and on-line HPLC) are slowing adoption of PAT in continuous purification, and as a consequence holding back continuous chromatography itself. ....

Alexander Armstrong , Stephen Goldrick , Kieran Horry , University College London ,