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Polycystic Kidney Disease Treatment: Gene Target Identified at Yale

An unsuspected gene, Glis2, has been found to be a target of polycystic kidney disease (PKD) signaling in preclinical models. ....

Yiqiang-cai , Hongyu-zhao , Zemeng-wei , Jianlei-gu , Michael-rehman , Stefan-somlo , Monkol-lek , Cho-steven-pei , Chao-zhang , Felix-behrens , Antonm-jetten , Thomasa-bell

A new drug candidate can shrink kidney cysts

A new drug candidate can shrink kidney cysts
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Denise-andrade , Sallys-liu , Bogdan-fedeles , Betsyp-leitch , Stefan-somlo , Sakunchai-khumsubdee , Sorin-fedeles , Robert-croy , John-essigmann , Jake-campolo , Research-scientist-nina-gubina , National-institute-of-environmental-health-sciences

Cancer drug holds promise for shrinking polycystic kidney cysts

Autosomal dominant polycystic kidney disease (ADPKD), the most common form of polycystic kidney disease, can lead to kidney enlargement and eventual loss of function. ....

Bogdan-fedeles , Sakunchai-khumsubdee , Robert-croy , Stefan-somlo , Betsyp-leitch , Sorin-fedeles , Jake-campolo , John-essigmann , Sallys-liu , Denise-andrade , Yale-university-school-of-medicine , National-institute-of-environmental-health-sciences

A new drug candidate can shrink kidney cysts

A compound originally developed as a cancer treatment may hold promise for treating polycystic kidney disease (ADPKD), which affects more than half a million Americans and can lead to kidney enlargement and loss of function. ....

Jake-campolo , Stefan-somlo , Robert-croy , Betsyp-leitch , Denise-andrade , Sallys-liu , Sakunchai-khumsubdee , Sorin-fedeles , Bogdan-fedeles , John-essigmann , Research-scientist-nina-gubina , Environmental-health-sciences