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Finding coronavirus's helper proteins


EMBL scientists identify human proteins hijacked by coronavirus, offering potential drug targets
EMBL scientists used a biophysical method called thermal proteome profiling (TPP) to gain a comprehensive overview of which human proteins are functionally altered at different times during SARS-CoV-2 infection. Credit: Holly Joynes/EMBL
A group of scientists led by EMBL’s Mikhail Savitski, Nassos Typas, and Pedro Beltrao, and collaborator Steeve Boulant at Heidelberg University Hospital, have analysed how the novel coronavirus affects proteins in human cells. They identified several human proteins as potential drug targets to prevent viral replication.
The researchers used a biophysical method called thermal proteome profiling (TPP) to gain a comprehensive overview of which human proteins are functionally altered during SARS-CoV-2 infection. TPP monitors protein amounts and denaturation temperatures – the points at which proteins heat up so much that they lose their ....

Baden Wuberg , Holly Joynes , Mikhail Savitski , Nassos Typas , Pedro Beltrao , Technical University Of Munich , European Bioinformatics Institute , Steeve Boulant At Heidelberg University Hospital , Heidelberg University Hospital , German Cancer Research Center , Steeve Boulant , Genome Biology Unit , Core Facility , Bioinformatics Institute , Technical University , University Of Munich , Cancer Research , Corona Virus , ஹோலி ஜாய்ன்ஸ் , பேடரோ பெல்ட்ராவ் , தொழில்நுட்ப பல்கலைக்கழகம் ஆஃப் முனிச் , ஐரோப்பிய உயிர் தகவலியல் நிறுவனம் , ஹைடெல்பெர்க் பல்கலைக்கழகம் மருத்துவமனை , ஜெர்மன் புற்றுநோய் ஆராய்ச்சி மையம் , மரபணு உயிரியல் அலகு , கோர் வசதி ,