Researchers have developed a new strain of vaccinia virus, which can replicate in tumor cells while maintaining increased immunogenicity. Specifically, it can to induce so-called immunogenic cell death in tumor cells.
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Vaccinia viruses are therapeutic tools with different biomedical applications depending on the susceptibility characteristics. For example, the strain called MVA (modified vaccinia Ankara), which is unable to replicate in mammalian cells, triggers a potent immune system response and is used to develop vaccines against COVID-19 or AIDS.
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