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Journal of Virology publishes paper on Rational Vaccines live-attenuated vaccine candidate


The major finding of the study, Herpes Simplex Virus 1 (HSV-1) 0ΔNLS Live-Attenuated Vaccine Protects against Ocular HSV-1 Infection in the Absence of Neutralizing Antibody in HSV-1 gB T Cell Receptor-Specific Transgenic Mice, found that the company s RVX101 vaccine candidate used to immunize a unique mouse line (does not generate much of a neutralizing antibody response to the virus) was shown to provide highly protective immunity and prevent herpes-associated neovascularization. This robust efficacy was found to be correlated with CD8+ T cells, since depleting these cells after vaccination, but before challenge with HSV-1 eliminated any efficacy realized by the vaccine. 
Ocular HSV can cause disease in any layer of the eye and is mainly spread by direct contact. A variety of eye diseases are associated with ocular HSV infection, including conjunctivitis, iridocyclitis, acute retinal necrosis and keratitis. ....

United Kingdom , Agustin Fernandez , Danieljj Carr , Stantonl Young , University Of Oklahoma Health Sciences Center , Department Of Ophthalmology , United Statesa , Oklahoma Health Sciences , Rational Vaccine , Rational Vaccines , ஒன்றுபட்டது கிஂக்டம் , பல்கலைக்கழகம் ஆஃப் ஓக்லஹோமா ஆரோக்கியம் அறிவியல் மையம் , துறை ஆஃப் கண் மருத்துவம் , ஓக்லஹோமா ஆரோக்கியம் அறிவியல் , ர்யாஶநல் தடுப்பூசி , ர்யாஶநல் தடுப்பு மருந்துகள் ,