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We're zeroing in on the "holy grail" of vaccine immunity


Katherine Wu
Jul 24, 2021 9:45 PM ET
She was able to confirm that in June through a simple test that searched her blood for antibodies that recognize the rubella virus, and then added them up. If her antibody counts were above a certain level, called a correlate of protection, she and her babies would be considered well shielded from disease. “You are considered immune with a titer of 9.9 to rubella,” she tweeted last month, referring to her antibody levels. “My titer? 116. I love my immune system sometimes.”
The term correlate of protection doesn’t exactly roll off the tongue, but it’s one of the sexiest concepts in the field of vaccinology. Correlates are biological benchmarks measurements of a single immune molecule or cell that can show that a vaccine is achieving its desired effect. With a correlate in hand, researchers can confirm how well a shot is working and identify the rare individuals in whom it doesn’t take; they can suss out the need for boo ....

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