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University of Freiburg s Nils Wiedemann Inducted into Academia Europaea – India Education | Latest Education News | Global Educational News

University of Freiburg s Nils Wiedemann Inducted into Academia Europaea – India Education | Latest Education News | Global Educational News
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United kingdomNils wiedemannBritish royal societyUniversity of freiburgCentre for integrative biological signallingSpemann graduate schoolInstitute of biochemistryMolecular biologyIntegrative biological signalling studies

Formation of pores in mitochondrial membrane elucidated

· Study by a team of researchers from Freiburg and Kyoto investigates formation of beta-barrel membrane proteins that make up the pores · ..

Nils wiedemannNikolaus pfannerToshiya endoCentre for biological signallingInstitute of biochemistrySpemann graduate school of biologyUniversity of freiburgKyoto sangyo universityUniversity of kyoto japanCentre for integrative biological signallingNature structuralMolecular biologyIntegrative biological signalling studiesBiological signalling studiesSpemann graduate school

Researchers solve the structure, function of mitochondrial sorting and assembly machinery

Researchers solve the structure, function of mitochondrial sorting and assembly machinery Mitochondria are vital for the human body as cellular powerhouses: They possess more than 1,000 different proteins, required for many central metabolic pathways. Disfunction of these lead to severe diseases, especially of the nervous system and the heart. In order to transport proteins and metabolites, mitochondria contain a special group of so-called beta-barrel membrane proteins, which form transport pores in the outer mitochondrial membrane. So far, scientists have not been able to explain the operating mode of the sorting and assembly machinery (SAM) for the biogenesis of these beta-barrel proteins.

Nordrhein westfalenNils wiedemannThomas beckerNikolaus pfannerEmily hendersonToshiya endoSpemann graduate school of biologyInstitute of biochemistryUniversity of bonnUniversity of freiburgKyoto university japanMolecular biologySpemann graduate schoolNervous systemனோற்ர்ேன் வெஸ்ட்ஃபாலன்நில்ஸ் விெதேமாங்ன்

Basis for the essential cellular powerhouses

E-Mail IMAGE: Model of beta-barrel membrane protein pore biogenesis at the sorting and assembly machinery (SAM) of the outer mitochondrial membrane. view more Credit: Illustration: Nils Wiedemann Mitochondria are vital for the human body as cellular powerhouses: They possess more than 1,000 different proteins, required for many central metabolic pathways. Disfunction of these lead to severe diseases, especially of the nervous system and the heart. In order to transport proteins and metabolites, mitochondria contain a special group of so-called beta-barrel membrane proteins, which form transport pores in the outer mitochondrial membrane. So far, scientists have not been able to explain the operating mode of the sorting and assembly machinery (SAM) for the biogenesis of these beta-barrel proteins. A team led by Prof. Dr. Toshiya Endo from Kyoto University/Japan, Prof. Dr. Nils Wiedemann and Prof. Dr. Nikolaus Pfanner from the University of Freiburg and Prof. Dr. Thomas

Nordrhein westfalenNils wiedemannThomas beckerNikolaus pfannerToshiya endoInstitute of biochemistrySpemann graduate school of biologyUniversity of bonnUniversity of freiburgKyoto university japanMolecular biologySpemann graduate schoolCell biologyMedicine healthனோற்ர்ேன் வெஸ்ட்ஃபாலன்நில்ஸ் விெதேமாங்ன்