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Study sheds light on how SARS-CoV-2 virus switches between replication and packaging

Immediately after the infection of a cell in the throat or lungs, the SARS-CoV-2 virus works very hard to replicate, using the human cell's metabolic pathways to produce its proteins and make sure that its genetic material (the RNA genome) is copied. ....

Megan Craig , Andreas Schlundt , Sophie Korn , Institute For Molecular Biosciences , Goethe University Frankfurt , Molecular Biosciences , Biomolecular Magnetic Resonance , Goethe University , Ars Cov 2 , X Ray ,

SARS-CoV-2: The grasping fingers of the viral N protein

SARS-CoV-2: The grasping fingers of the viral N protein
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Sophie Marianne Korn , Sophie Korn , Andreas Schlundt , Institute For Molecular Biosciences , Goethe University Frankfurt , Nature Communications , Goethe University , Molecular Biosciences , Biomolecular Magnetic Resonance ,

SARS-CoV-2: The grasping fingers of the viral

SARS-CoV-2 viruses manage to hijack human cells with a minimum of their own proteins and use them as incubators for their offspring. One of these multifunctional viral proteins is the nucleocapsid protein (N), which plays a key role in viral replication and packaging. Researchers from Goethe University Frankfurt have now discovered how N recognizes both viral RNA in general as well as specific RNA positions with the help of “fingers”. In the latter, N adapts to the increased temperature of the host cell. It might be the case that SARS-CoV-2 uses the fever we develop in the course of an infection to switch from virus replication to virus release. ....

Sophie Korn , Andreas Schlundt , Method Of Research , Nature Communications , Institute For Molecular Biosciences , Goethe University Frankfurt , Molecular Biosciences , Biomolecular Magnetic Resonance ,