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Sara Cooper and colleagues argue that a better understanding of the complex sociopolitical drivers of distrust in vaccination will increase the potential of social media to rebuild vaccine confidence Vaccination experts have become increasingly alarmed about the continued waning of public confidence in vaccines.1 Social media are considered to be major contributors to this decline, facilitating the rapid and widespread sharing of misinformation, enabling vaccine anxieties and rumours to travel rapidly around the world.23 Social media are also seen to have enabled vocal anti-vaccination groups to self-organise and communicate well beyond their local areas.45 The covid-19 pandemic has only magnified these concerns,6 as Tedros Adhanom Ghebreyesus, director general of the World Health Organization put it, “We’re not just fighting a pandemic; we’re fighting an infodemic.”7 This dominant narrative on mistrust in vaccines assumes that it is primarily the result of a lack of informa

Sri lankaSouth africaUnited kingdomDemocratic republic of the generalDemocratic republic of the congoSierra leoneDavid kaawa mafigiriHeidi larsonTedros adhanom ghebreyesusSara cooperCharless wiysongeCharles shey wiysongeAlison buttenheimMuktara gadanyaEmma veitchEvansonz sambala