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Why Researchers Look to Gut Microbial Metabolites in Parkins... : Neurology Today


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Findings highlight significant differences in the fecal microbiome and metabolome in patients with Parkinson s disease and control subjects, demonstrating an important connection between the brain and gut that could influence the disease process and progression.
A team of international investigators has identified significant differences in the fecal microbiome and metabolome in patients with Parkinson s disease (PD) and control subjects, suggesting an important link between the gut and brain that could play a role in the disease process.
The role of gut microbes in neurodegenerative disorders, including PD, has garnered increasing attention in recent years, as the disease s motor symptoms are often accompanied by non-motor features such as gastrointestinal problems, cognitive decline, and weight loss. ....

Rush University Medical Center , United States , United Kingdom , British Columbia , Chun Wie Chong , Ali Keshavarzian , Josephinem Dyrenforth , Silke Appel Cresswell , Monash University Malaysia , Institute For Advanced Study Of The Gut , University Of Malaya , University Of British Columbia , Djavad Mowafaghian Centre For Brain Health , Huey Tan , Food Frequency Questionnaire , Advanced Study , Marg Meikle Professor , Djavad Mowafaghian Centre , Brain Health , அவசரம் பல்கலைக்கழகம் மருத்துவ மையம் , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , பிரிட்டிஷ் கொலம்பியா , சுன் வீ சோங் , சில்கே பாபேல் கிரேஸிஸ்வீல்ல , மோனாஷ் பல்கலைக்கழகம் மலேசியா ,

Study examines association between gut mycobiome and Parkinson's disease


Study examines association between gut mycobiome and Parkinson’s disease
The bacterial gut microbiome is strongly associated with Parkinson s disease (PD), but no studies had previously investigated he role of fungi in the gut. In this novel study published in the
Journal of Parkinson s Disease, a team of investigators at the University of British Columbia examined whether the fungal constituents of the gut microbiome are associated with PD. Their research indicated that gut fungi are not a contributing factor, thereby refuting the need for any potential anti-fungal treatments of the gut in PD patients.
Several studies conducted since 2014 have characterized changes in the gut microbiome. Most existing studies, however, employ bacterial-specific sequencing. To date, a potential role for the fungal constituents of the gut microbiome, also known as the mycobiome, has remained unexplored. ....

United Kingdom , Silke Appel Cresswell , Emily Henderson , University Of British Columbia , Djavad Mowafaghian Centre For Brain Health , Division Of Neurology , Pacific Parkinson Research Centre , British Columbia , Lead Investigator , Pacific Parkinson , Research Centre , Djavad Mowafaghian Centre , Brain Health , Parkinson 39s Disease , ஒன்றுபட்டது கிஂக்டம் , சில்கே பாபேல் கிரேஸிஸ்வீல்ல , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் பிரிட்டிஷ் கொலம்பியா , பிரிவு ஆஃப் நரம்பியல் , பெஸிஃபிக் பார்கின்சன் ஆராய்ச்சி மையம் , பிரிட்டிஷ் கொலம்பியா , வழி நடத்து புலனாய்வாளர் , பெஸிஃபிக் பார்கின்சன் , ஆராய்ச்சி மையம் , மூளை ஆரோக்கியம் ,

Study suggests that gut fungi are not associated with Parkinson's disease


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IMAGE: Stacked bar plot of the top nine most abundant fungal genera in controls and PD patients. Credit: Journal of Parkinson s Disease.
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Credit: Parkinson Canada/Parkinson Society British Columbia
Amsterdam, NL, January 21, 2021 - The bacterial gut microbiome is strongly associated with Parkinson s disease (PD), but no studies had previously investigated he role of fungi in the gut. In this novel study published in the
Journal of Parkinson s Disease, a team of investigators at the University of British Columbia examined whether the fungal constituents of the gut microbiome are associated with PD. Their research indicated that gut fungi are not a contributing factor, thereby refuting the need for any potential anti-fungal treatments of the gut in PD patients. ....

United Kingdom , Noord Holland , Silke Appel Cresswell , University Of British Columbia , Djavad Mowafaghian Centre For Brain Health , Division Of Neurology , Pacific Parkinson Research Centre , British Columbia , Pacific Parkinson , Research Centre , Djavad Mowafaghian Centre , Brain Health , Medicine Health , Parkinsons Disease , ஒன்றுபட்டது கிஂக்டம் , நூற்த் ஹாலண்ட் , சில்கே பாபேல் கிரேஸிஸ்வீல்ல , பல்கலைக்கழகம் ஆஃப் பிரிட்டிஷ் கொலம்பியா , பிரிவு ஆஃப் நரம்பியல் , பெஸிஃபிக் பார்கின்சன் ஆராய்ச்சி மையம் , பிரிட்டிஷ் கொலம்பியா , பெஸிஃபிக் பார்கின்சன் , ஆராய்ச்சி மையம் , மூளை ஆரோக்கியம் , மருந்து ஆரோக்கியம் , பார்கின்சன்ஸ் நோய் ,