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Maternal Immune Activation Induces Sustained Changes in Fetal Microglia Motility


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Credit: Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine
Researchers at the Kobe University Graduate School of Medicine have revealed that alterations in fetal microglia ( 1) resulting from maternal inflammation could contribute towards the onset of developmental and psychiatric disorders. The research team including PhD student OZAKI Kana and Professor YAMADA Hideto et al. from the Department of Obstetrics and Gynecology observed that infant mice that were exposed to maternal immune activation (MIA mice) displayed changes in microglial process motility during gestation and development. These changes remained after birth and were linked to social behavior deficits, such as those that are found in autism spectrum disorders. ....

Daisuke Kato , Koichiro Haruwaka , Kana Ozaki , Andrewj Moorhouse , Zhongtian Guo , Shouta Sugio , Akari Hashimoto , Hideto Yamada , Ako Ikegami , Midori Shibushita , Tsuyako Tatematsu , Research Findings , Nagoya University , Department Of Obstetrics , Kobe University Graduate School Of Medicine , University Of New South Wales , Research Background , Kobe University Graduate School , Associate Professor , New South , Scientific Reports , கானா ஒஜாக்கி , ஆராய்ச்சி கண்டுபிடிப்புகள் , நாகோயா பல்கலைக்கழகம் , துறை ஆஃப் மகப்பேறியல் , கோபி பல்கலைக்கழகம் பட்டதாரி பள்ளி ஆஃப் மருந்து ,