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Disruption of the autism gene and chromatin regulator KDM5A alters hippocampal cell identity

Disruption of the autism gene and chromatin regulator KDM5A alters hippocampal cell identity
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Technology to Catalog Every Human Brain Cell Developed

Technology to Catalog Every Human Brain Cell Developed
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This brain circuit signals when to stop eating; could regulating it help with obesity

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Like a good story, feeding has a beginning, a middle and an end. It begins with appetite prompting the search for food, continues with eating the food and it ends when satiation hits and the consumption of food is stopped.
At Baylor College of Medicine, Dr. Qi Wu, Dr. Yong Han and their colleagues have uncovered new aspects of the last part of this story that relate to the little-known neural circuits and neurotransmitters involved in ending food consumption.
The team discovered a novel circuit that connects a unique subset of dopamine-producing neurons with downstream neurons in the hindbrain (lower brainstem) and potently suppresses food intake by triggering satiation in mice. They also found that the FDA-approved drug methylphenidate (MPH) mediates its noticeable weight loss effect by activating this particular circuit, opening the possibility that regulating this circuit might help people control weight. The study appears in the journal ....

United States , South Korea , Yong Xu , Kyong Han , Monica Farias , Qi Wu , Guobin Xia , American Heart Association , Pew Charitable , Sciences Advances , American Diabetes Association , Pew Scholarship Of Biomedical Sciences , Baylor Collaborative Faculty Research Investment Program , Centers Of Biomedical Research Excellence , Digestive Diseases Center , College Of Medicine , Baylor College Of Medicine , Baylor College , Shared Instrumentation , Diseases Center , Pew Charitable Trust , Faculty Start Up , Biomedical Research Excellence , Pew Scholarship , Biomedical Sciences , ஒன்றுபட்டது மாநிலங்களில் ,

Can regulating a novel brain circuit help control obesity?

Like a good story, feeding has a beginning, a middle and an end. It begins with appetite prompting the search for food, continues with eating the food. ....

United States , South Korea , Yong Xu , Kyong Han , Monica Farias , Qi Wu , Guobin Xia , American Heart Association , Pew Charitable , Sciences Advances , American Diabetes Association , Pew Scholarship Of Biomedical Sciences , Baylor Collaborative Faculty Research Investment Program , Centers Of Biomedical Research Excellence , Digestive Diseases Center , Baylor College Of Medicine , Baylor College , Shared Instrumentation , Diseases Center , Pew Charitable Trust , Faculty Start Up , Biomedical Research Excellence , Pew Scholarship , Biomedical Sciences , Brain Activity , Heart Disease ,