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Study suggests key to antipsychotic-drug–induced obesity

Study suggests key to antipsychotic-drug–induced obesity
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Shangang Zhao , Philipp Scherer , Touchstone Center , Diabetes Research , Ut Southwestern Medical Center , Science Translational Medicine , Internal Medicine , Science Translational ,

Study suggests key to antipsychotic drug-induced obesity

An increased concentration of the hormone leptin in fat cells is believed to be responsible for weight gain associated with antipsychotic drugs, according to re ....

United States , Chen Liu , Xue Nan Sun , Joelk Elmquist , Qingzhang Zhu , Jan Bernd Funcke , Chao Li , Shangang Zhao , Stevenc Wyler , Christinem Kusminski , Carlh Westcott , Philipp Scherer , Shiuhwei Chen , Peter Odonnell Jr , Roya Brinkley , Jyun Wang , Qian Lin , Voelcker Fund Young Investigator Pilot Award , Research Institute Of Texas , Minnie Tomerlin Voelcker Fund , Southwestern Nutrition Obesity Research Center , Brain Institute , American Heart Association , Doh Lab , Southwestern Medical Center , Hypothalamic Research ,

Study suggests key to antipsychotic drug-induced obesity

An increased concentration of the hormone leptin in fat cells is believed to be responsible for weight gain associated with antipsychotic drugs, according to re ....

United States , Shangang Zhao , Stevenc Wyler , Christinem Kusminski , Carlh Westcott , Xue Nan Sun , Chen Liu , Joelk Elmquist , Jan Bernd Funcke , Qingzhang Zhu , Chao Li , Peter Odonnell Jr , Roya Brinkley , Jyun Wang , Qian Lin , Philipp Scherer , Shiuhwei Chen , Doh Lab , Southwestern Medical Center , American Heart Association , Diabetes Research , Hypothalamic Research , Senior Research , Touchstone Center , National Institutes Of Health , National Institute Of Diabetes ,

Swapping alpha cells for beta cells to treat diabetes

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IMAGE: At left is a healthy islet with many insulin-producing cells (green) and few glucagon-producing cells (red). At right, this situation is altered in a diabetic islet with a heavy preponderance.
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Credit: UT Southwestern Medical Center
Blocking cell receptors for glucagon, the counter-hormone to insulin, cured mouse models of diabetes by converting glucagon-producing cells into insulin producers instead, a team led by UT Southwestern reports in a new study. The findings, published online in
PNAS, could offer a new way to treat both Type 1 and Type 2 diabetes in people.
More than 34 million Americans have diabetes, a disease characterized by a loss of beta cells in the pancreas. Beta cells produce insulin, a hormone necessary for cells to absorb and use glucose, a type of sugar that circulates in the blood and serves as cellular fuel. ....

United States , Derekc Leonard , Shangang Zhao , Eli Lilly , Williaml Holland , Young Lee , Rogerh Unger , Jyun Wang , Shiuhwei Chen , Ezekiel Quittner Strom , Philippe Scherer , Xinxin Yu , Yiyi Zhang , Zhuzhen Zhang , National Institute Of Diabetes , Kidney Human Islet Research Network , National Institutes Of Health , University Of Utah , Diabetes Research , Touchstone Center , Diabetes Research Foundation , Department Of Veterans Affairs , Touchstone Diabetes Center , May Yun Wang , Distinguished Chair , West Distinguished Chair ,

Two studies shed light on how, where body can add new fat cells

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IMAGE: An image showing a blood vessel in fat tissue, surrounded by fat progenitor cells (in green).
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Credit: UT Southwestern Medical Center
DALLAS - Feb. 3, 2021 - Gaining more fat cells is probably not what most people want, although that might be exactly what they need to fight off diabetes and other diseases. How and where the body can add fat cells has remained a mystery - but two new studies from UT Southwestern provide answers on the way this process works.
The studies, both published online today in
Cell Stem Cell, describe two different processes that affect the generation of new fat cells. One reports how fat cell creation is impacted by the level of activity in tiny organelles inside cells called mitochondria. The other outlines a process that prevents new fat cells from developing in one fat storage area in mice - the area that correlates with the healthy subcutaneous fat just under the skin in humans. (Both studies ....

United States , Christym Gliniak , Bo Shan , Christinem Kusminski , Viviana Paschoal , Philipp Scherer , Lukei Szweda , Rana Gupta , Abdallah Elnwasany , Ruth Gordillo , Nolwenn Joffin , Lavanya Vishvanath , Clair Crewe , Shangang Zhao , Gervaiseh Henry , Chelsea Hepler , Mengle Shao , Qianbin Zhang , Scientific Research , American Heart Association , National Institute Of Diabetes , National Institutes Of Health , Diabetes Research , American Diabetes Association , Touchstone Center , National Academy Of Medicine ,