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Frontiers | Contribution of the Gut Microbiota to Intestinal Fibrosis in Crohn's Disease

In Crohn’s disease (CD), intestinal fibrosis is a critical determinant of a patient’s prognosis. Although inflammation may be a prerequisite for the initiation of intestinal fibrosis, research shows that the progression or continuation of intestinal fibrosis can occur independently of inflammation. Thus, once initiated, intestinal fibrosis may persist even if medical treatment controls inflammation. Clearly, an understanding of the pathophysiological mechanisms of intestinal fibrosis is required to diminish its occurrence. Accumulating evidence suggests that the gut microbiota contributes to the pathogenesis of intestinal fibrosis. For example, the presence of antibodies against gut microbes can predict which CD patients will have intestinal complications. In addition, microbial ligands can activate intestinal fibroblasts, thereby inducing the production of extracellular matrix. Moreover, in various animal models, bacterial infection can lead to the development of intestinal fibros ....

United Kingdom , Japan General , Nat Genet , Fabio Cominelli , Van Immerseel , Darfeuille Michauda Crohn , J Gastroenterol Hepatol , Nat Protoc , Taylor Kd Yu , Nasr El Yafi , Semin Immunopathol , Gastroenterol Hepatol , Waal Malefytr Glimcher , Hansen Jm Li , Scandj Gastroenterol , National Institutes Of Health , Powrief Cytokine Networks , Japan Society For The Promotion Of Science , Uehara Memorial Foundation , Fibrosis Development , Postdoctoral Fellowship For Research , Gut Microbiota , Intestinal Fibrosis , Microbial Stimulation , Fibroblasts Through Microbial , Fibroblasts Through ,