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Raman Probe Detects Enzyme Expression in Heterogeneous Tissues

Raman Probe Detects Enzyme Expression in Heterogeneous Tissues
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United States , Yasuteru Urano , Hiroyoshi Fujioka , Yoshihiro Misawa , Ayumi Komazawa , Ryosuke Kojima , Takaha Mizuguchi , Minoru Kawatani , Spencer John Spratt , Fumiaki Obata , Yasuyuki Ozeki , International Research Frontiers Initiative , School Of Biostudies , Tokyo Institute Of Technology , University Of Tokyo , Department Of Electrical Engineering , School Of Pharmaceutical Sciences , Department Of Life Science , Kyoto University , School Of Engineering , Living Systems Materialogy Lism Research Group , School Of Medicine , Biosystems Dynamics Research , Tokyo Institute Of Technology Tech , Journal Of The American Chemical Society , Tokyo Tech ,

Highly sensitive Raman probe detects enzyme e

Raman imaging offers a greater potential for detecting multiple enzyme activities than fluorescence imaging, demonstrate Tokyo Tech researchers by developing 9CN-rhodol-based activatable Raman probes using a novel mechanism for Raman signal activation. The strategy allows a synthesis of highly activatable Raman probes with high aggregation and multiplexing ability, making it a promising tool for extending the range of Raman probes for the detection of multiple enzyme activities in heterogeneous biological tissues. ....

United States , Yasuyuki Ozeki , Hiroyoshi Fujioka , Journal Of The American Chemical Society , Tokyo Institute Of Technology , University Of Tokyo , Tokyo Institute Of Technology Tech , Method Of Research , Tokyo Tech , Professor Mako Kamiya , Assistant Professor Hiroyoshi Fujioka , Tokyo Institute , American Chemical , Selective Ex Vivo ,