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Mixed Results for Immunotherapy in Metastatic Prostate Cancer

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An immunotherapy combination for metastatic castration-resistant prostate cancer (mCRPC) failed to hit a response target but still exceeded historical results, a small prospective study showed.
Ten of 35 (28.6%) patients responded to the combination of nivolumab (Opdivo) and ipilimumab (Yervoy). The activity fell short of the 40% threshold for a positive outcome but well above the historical response rate for immunotherapy in patients previously treated with docetaxel.
The safety profile of the combination was consistent with prior clinical experience, reported Mark Linch, MD, PhD, of University College London, at the American Association for Cancer Research virtual meeting.
Responders were enriched with patients with mismatch repair or BRCA 1 and 2, said Linch. We believe that further study of nivolumab and ipilimumab i biomarker-selected patients with metastatic castration-resistant prostate cancer is warranted. The rate of incomplete treat ....

United States , Charles Bankhead , University College London , American Association For Cancer Research , Mark Linch , American Association , Cancer Research , Medpage Today , Carcinoma Of Prostate , Malignant Tumor Of Prostate , Secondary Malignant Neoplastic Disease , ஒன்றுபட்டது மாநிலங்களில் , சார்லஸ் வங்கித் தலை , பல்கலைக்கழகம் கல்லூரி லண்டன் , அமெரிக்கன் சங்கம் க்கு புற்றுநோய் ஆராய்ச்சி , அமெரிக்கன் சங்கம் , புற்றுநோய் ஆராய்ச்சி , புற்றுநோய் ஆஃப் ப்ராஸ்டேட் , வீரியம் மிக்கது கட்டி ஆஃப் ப்ராஸ்டேட் ,

Entrectinib Impresses in Certain Lung Cancers

Crizotinib (Xalkori) has approval as first-line therapy for
ROS1 fusion-positive metastatic NSCLC but has poor CNS penetration, the authors noted, adding that in about half of patients treated with crizotinib, initial progression occurs only in the CNS.
Entrectinib is designed to cross the blood-brain barrier, and preclinical studies showed that the agent achieves high CNS concentrations, which were associated with strong efficacy in brain-tumor models.
Integrated Analysis
For the analysis, the investigators evaluated entrectinib in three phase I or II clinical trials of patients with locally advanced or metastatic
ROS1 fusion-positive NSCLC. A preliminary analysis of a 53-patient efficacy-evaluable population showed a 77% objective response rate (ORR) and a median duration of response (DoR) of 24.6 months. ....

New York , United States , Memorial Sloan Kettering Cancer Center , Fabrice Barlesi , Anna Farago , Alexander Drilon , Charles Bankhead , Crizotinib Xalkori , Hospital Cancer Center , Gustave Roussy Cancer Campus , New York City , Massachusetts General Hospital Cancer Center , Medpage Today , Non Small Cell Lung Cancer , Secondary Malignant Neoplastic Disease , Lung Cancer , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , நினைவகம் ஸ்லோன் கெட்டரிங் புற்றுநோய் மையம் , அண்ணா ஃபராகோ , சார்லஸ் வங்கித் தலை , மருத்துவமனை புற்றுநோய் மையம் , புதியது யார்க் நகரம் , மாசசூசெட்ஸ் ஜநரல் மருத்துவமனை புற்றுநோய் மையம் , அல்லாத சிறிய செல் நுரையீரல் புற்றுநோய் , நுரையீரல் புற்றுநோய் ,

Radiotherapy's Role in Metastatic Prostate Cancer Clarified

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Adding radiation therapy to standard treatment improved failure-free survival (FFS) and overall survival for prostate cancer patients with only a few bone metastases, an exploratory analysis of the multi-arm, multi-stage STAMPEDE trial found.
Among the nearly 2,000 men in the study, adding radiation to mostly androgen deprivation therapy (ADT) improved both FFS (HR 0.57, 95% CI 0.47-0.70) and overall survival (HR 0.62, 95% CI 0.46-0.83) in those with only non-regional lymph node metastasis or with fewer than three bone lesions and no visceral metastases, reported Noel Clarke, MBBS, of the Christie NHS Foundation Trust in Manchester, England, and colleagues.
Patients either with visceral metastasis or four or more bone lesions still had improved FFS (HR 0.87, 95% CI 0.76-0.99, ....

North Carolina , United States , Duke University , Bridget Koontz , Noel Clarke , Thomas Hope , Ian Ingram , Duke University School Of Medicine , University Of California San Francisco , Foundation Trust In Manchester , Duke University School , California San Francisco , Medpage Today , Deputy Managing Editor , Secondary Malignant Neoplastic Disease , Disorder Of Skin , Eruption Of Skin , Carcinoma Of Prostate , Malignant Tumor Of Prostate , வடக்கு கரோலினா , ஒன்றுபட்டது மாநிலங்களில் , டியூக் பல்கலைக்கழகம் , பிரிட்ஜெட் கூன்ட்ஸ் , நோயல் கிளார்க் , தாமஸ் நம்பிக்கை , ஈயந் இஂக்ரம் ,

Struggling to Vaccinate New York's Home Care Workers

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At the beginning of January, an oft-overlooked sector of the frontline healthcare workforce scored a significant win in New York state: officials classified home healthcare workers as priority 1A to receive COVID-19 vaccines, a move pushed by advocacy groups and unions.
But weeks later, many home healthcare agencies in the state especially smaller ones with limited resources are facing new challenges in getting their personnel inoculated.
There are shortages of the vaccine, and difficulties reaching a decentralized workforce. Most agencies lack the resources to set up their own inoculation sites, and vaccine hesitancy is still a significant concern. ....

New York , United States , Andria Castellanos , Joe Pecora , Roger Noyes , York Department Of Health , Greater New York Hospital Association , Nurse Service Of New York , Home Care Association Of New York , Home Care Association , New York State , New Yorkers , Home Healthcare Workers , New York Department , Visiting Nurse Service , New York City , Grand Central Terminal , Delay When Starting To Pass Urine , Secondary Malignant Neoplastic Disease , Co Vid , Covid 19 , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , ஆண்ட்ரியா காஸ்டெல்லானோஸ் , ஓஹோ பேகோர , ரோஜர் இல்லை ஆம் ,

ICI Colitis More Common in Metastatic Disease

Abdominal CT findings also predicted colitis during ICI cancer treatment ....

United States , Mayo Clinic In Rochester , Elida Voth , Colitis Congress , Medpage Today , Mayo Clinic , Common Terminology Criteria , Adverse Events , Secondary Malignant Neoplastic Disease , Malignant Neoplastic Disease , Retention Of Urine , ஒன்றுபட்டது மாநிலங்களில் , மயோ சிகிச்சையகம் இல் ரோசெஸ்டர் , எலிடா வோத் , பெருங்குடல் அழற்சி காங்கிரஸ் , மயோ சிகிச்சையகம் , பொதுவானது சொல் அளவுகோல்கள் , பெருங்குடல் அழற்சி , தக்கவைத்தல் ஆஃப் சிறுநீர் ,