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Unlocking the Mysteries of the Heart: Breakthrough Research Reveals Sarcomere Secrets

Unlocking the Mysteries of the Heart: Breakthrough Research Reveals Sarcomere Secrets
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City Of , United Kingdom , Mathias Gautel , Pauline Bennett , Martin Rees , Lin Kho , Sebastian Tacke , Markus Stabrin , Zhexin Wang , Stefan Raunser , Davide Tamborrini , Thorsten Wagner , Michael Grange , Filament Structure , Relaxed Cardiac Sarcomere ,

What Can We Discover with a 3-in-1 Microscope?

A recently conducted study by physicists from TU Delft in the Netherlands has demonstrated a sub-nanometer resolution, cryogenic electron tomography (cryo-ET) capable of in-situ observation of macromolecular complexes. ....

Zuid Holland , Arjenj Jakobi , Roger Wepf , Daanb Boltje , Zhexin Wang , Abrahamj Koster , Jacobp Hoogenboom , Maxj Kaag , Agrela Pinto , Sebastian Tacke , Stefan Raunser , Ilamaran Sivarajahdec , Technology Networks , Further Reading , Grantj Jensen , Cecilia De Agrela Pinto , How Cryogenic Electron Microscopy , Advancing Battery , Aids Biomolecule Structural , Hree In One Microscope ,

Delmic licenses Cryo Workflow Tools developed together with Max Planck scientists

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IMAGE: A newly developed cryo Anti-contaminator (CERES Ice Shield) consists of a cryo shutter which protects the sample from ice contamination and thereby improves preparation of the sample by the ion-beam..
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Credit: MPI of Molecular Physiology
In comparison to the conventional light microscopy, cryo electron tomography is a powerful tool that offers much deeper insights into the cell structure by unveiling high-resolution 3D views of biological samples such as large macromolecules. In the first step, samples are immobilized by high-speed freezing at extreme temperatures under ?150 °C. These cryogenic conditions make it possible to study samples without chemical fixation or dehydration, thereby preventing distortion or disruption of biological structures of the sample. However, the preparation and the handling of the samples are very complex, since the formation of crystalline ice can compromise the structural integrity of the specimen. ....

Ingrid Kapser Fischer , Katherine Lau , Sebastian Tacke , Stefan Raunser , Max Planck Institute In Dortmund , Max Planck Institute Of Molecular Physiology , Max Planck Society , Cryo Workflow Tools , Focused Ion Beam , Transmission Electron Microscopy , Scanning Electron Microscope , Defence System , Max Planck Institute , Business Unit Owner , Max Planck Innovation , Molecular Physiology , Max Planck , Cell Biology , Molecular Biology , Health Care , Biomedical Environmental Chemical Engineering , க்யாதரிந் லாவ் , க்ரியோ பணிப்பாய்வு கருவிகள் , கவனம் அயன் உத்திரம் , பரவும் முறை எதிர் மின்னணு நுண்ணோக்கி , ஸ்கேனிங் எதிர் மின்னணு நுண்ணோக்கி ,