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COVID-19 infection in immunodeficient patient cured by infusing convalescent plasma


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IMAGE: Under FDA emergency-use authorization, doctors successfully resolved COVID-19 in a seriously ill, immunodeficient woman using a very high-neutralizing antibody-titer convalescent plasma from a recovered COVID-19 patient. However, further study suggested.
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Credit: UAB
BIRMINGHAM, Ala. - A 72-year-old woman was hospitalized with severe COVID-19 disease, 33 days after the onset of symptoms. She was suffering a prolonged deteriorating illness, with severe pneumonia and a high risk of death, and she was unable to mount her own immune defense against the SARS-CoV-2 virus because of chronic lymphocytic leukemia, which compromises normal immunoglobulin production.
But when physicians at the University of Alabama at Birmingham recommended a single intravenous infusion of convalescent blood plasma from her son-in-law who had recovered from COVID-19 disease a remarkable, beneficial change followed. Her physician, Randall Davis, M.D., ....

United States , New York , Rockefeller University , Weimin Liu , Theodora Hatziioannou , Regina Stoltz , Beatriceh Hahn , Lynn Prichard , Johnp Moore , Ashtonn Kornbrust , Thomasj Ketas , Sarah Sterrett , Toddp Mccarty , Pauld Bieniasz , Chrism Lough , Edluem Tabengwa , Davidt Redden , Yutao Hua , Sonyal Heath , Marisab Marques , Randall Davis , Kazuhito Honjo , Ronniem Russell , Paula Goepfert , National Institutes Of Health , Drug Administration ,

Study: Individuals recovering from COVID-19 helpful for Sustained cellular immune dysregulation


Study: Individuals recovering from COVID-19 helpful for Sustained cellular immune dysregulation
ANI |
Updated: Jan 03, 2021 22:10 IST
Birmingham [UK], January 3 (ANI): A recent study has determined that Covid-19 patients might be helpful for clinicians to better understand how the unknown SARS-CoV-2 virus acts.
According to a study published in the Journal of Clinical Investigation, many infected patients remain asymptomatic or have mild symptoms. Others, especially those with comorbidities, can develop severe clinical disease with atypical pneumonia and multiple system organ failures.
Since the first cases were reported in December 2019, the SARS-CoV-2 virus that causes COVID-19 has surged into a pandemic, with cases and deaths still mounting. Ongoing observational clinical research has become a priority to better understand how this previously unknown virus acts, and findings from this research can better inform treatment ....

Kelseye Lowman , Sangita Sarkar , Olaf Kutsch , Sushma Boppana , Steffanie Sabbaj , Kai Qin , Phillip Mudd , Kenneth Remy , Paul Goepfert , Manju Bansal , Sarah Sterrett , Mildredd Perez , Eric Carlin , Nathan Erdmann , James Kobie , Washington University , Department Of Biostatistics , School Of Public Health , Division Of Infectious Diseases , Department Of Medicine , University Of Alabama At Birmingham , Clinical Investigation , Infectious Diseases , சங்கிதா சர்க்கார் , சுஷ்மா போப்பனா , கை குயின் ,

Study finds sustained cellular immune dysregulation in patients recovering from COVID-19


Study finds sustained cellular immune dysregulation in patients recovering from COVID-19
ANI |
Updated: Jan 02, 2021 23:14 IST
Birmingham [UK], January 2 (ANI): Findings from recent researches on COVID-19 and observational clinical research of COVID-19 patients can help clinicians explore more about the virus to better inform treatment and vaccine design.
The University of Alabama at Birmingham researchers, led by first-author Jacob Jake Files and co-senior authors Nathan Erdmann, M.D., PhD, and Paul Goepfert, M.D., have now reported their observational study, Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection, published in the Journal of Clinical Investigation.
COVID-19, which has killed 1.7 million people worldwide, does not follow a uniform path. Many infected patients remain asymptomatic or have mild symptoms. Others, especially those with comorbidities, can develop severe cl ....

Kelseye Lowman , Olaf Kutsch , Sushma Boppana , Steffanie Sabbaj , Kai Qin , Phillip Mudd , Kenneth Remy , Paul Goepfert , Manju Bansal , Sarah Sterrett , Mildredd Perez , Sanghita Sarkar , Eric Carlin , Nathan Erdmann , James Kobie , Washington University , Department Of Biostatistics , School Of Public Health , Division Of Infectious Diseases , Department Of Medicine , University Of Alabama At Birmingham , Clinical Investigation , Infectious Diseases , சுஷ்மா போப்பனா , கை குயின் , பிலிப் சேறு ,

Sustained cellular immune dysregulation in individuals recovering from COVID-19


Jacob “Jake” Files COVID-19, which has killed 1.7 million people worldwide, does not follow a uniform path. 
Many infected patients remain asymptomatic or have mild symptoms. Others, especially those with comorbidities, can develop severe clinical disease with atypical pneumonia and multiple system organ failure. 
Since the first cases were reported in December 2019, the SARS-CoV-2 virus that causes COVID-19 has surged into a pandemic, with cases and deaths still mounting. Ongoing observational clinical research has become a priority to better understand how this previously unknown virus acts, and findings from this research can better inform treatment and vaccine design. 
University of Alabama at Birmingham researchers, led by first-author Jacob “Jake” Files and co-senior authors Nathan Erdmann, M.D., Ph.D., and Paul Goepfert, M.D., have now reported their observational study, “Sustained cellular immune dysregulation in individuals recovering from SARS-Co ....

Kelseye Lowman , Olaf Kutsch , Sushma Boppana , Steffanie Sabbaj , Kai Qin , Phillip Mudd , Kenneth Remy , Paul Goepfert , Manju Bansal , Sarah Sterrett , Mildredd Perez , Sanghita Sarkar , Eric Carlin , Nathan Erdmann , James Kobie , Washington University , Scientist Training Program , Department Of Biostatistics , School Of Public Health , Division Of Infectious Diseases , Department Of Medicine , University Of Alabama At Birmingham , Clinical Investigation , Infectious Diseases , Medical Scientist Training , Endowed Professorship ,