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Researchers describe the origin and fate of liver myofibroblasts

Hepatic fibrosis occurs when scar tissue replaces damaged cells in the liver. Over time, accumulating scarring distorts the liver, interferes with its blood supply and may progressively lead to worsening consequences, from cirrhosis to liver failure to liver cancer. ....

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Liver Cells' Transformation Into Scar Tissue Explored

Liver Cells' Transformation Into Scar Tissue Explored
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Survival is mixed matter for deadliest of pancreatic cancers

Survival is mixed matter for deadliest of pancreatic cancers
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Diet plays critical role in NASH progressing to liver cancer in mouse model

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IMAGE: Debanjan Dhar, PhD, is co-senior author of the study and assistant professor in the Department of Medicine, Division of Gastroenterology at UC San Diego School of Medicine.
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Credit: UC San Diego Health Sciences
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD patients are at higher risk of developing Non-alcoholic steatohepatitis (NASH), which causes severe and chronic liver inflammation, fibrosis and liver damage. A patient with NASH is believed to be at high risk for developing a form of liver cancer called hepatocellular carcinoma (HCC).
Apart from lifestyle interventions, there are currently no approved treatments for NASH. A liver transplant is sometimes the only remedy. ....

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Two anti-viral enzymes transform pre-leukemia stem cells into leukemia

Credit: UC San Diego Health Sciences
Since stem cells can continually self-regenerate, making more stem cells, and differentiate into many different specialized cell types, they play an important role in our development and health. But there can also be a dark side stem cells can sometimes become cancer stem cells, proliferating out of control and leading to blood cancers, such as leukemia and multiple myeloma. The self-renewing nature of cancer stem cells makes them particularly hard to eradicate, and they re often the reason a blood cancer reoccurs.
Researchers at UC San Diego Health and University of California San Diego School of Medicine are working to understand what pushes pre-cancer stem cells to transform into cancer stem cells and are developing ways to stop that switch. ....

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