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Neurons in remote brain regions drive glioblastoma infiltration

Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor. Despite treatment, GBM recurrence is inevitable and tends to occur outside surgical margins or in locations remote to the primary tumor, highlighting the central role played by tumor infiltration in this malicious disease. ....

Ali Jalali , Dongjoo Choi , Sanjana Murali , Ganesh Rao , Zhung Fu Lee , Benjamin Deneen , Yuhui Yang , Malcolm Mcdonald , Ehson Maleki , James Bayley , Emmet Huang Hobbs , Jeffreyl Noebels , Megan Craig , Michaelr Williamson , Mariank Blattner , Yeunjung Ko , Brittney Lozzi , Hsiao Chi Chen , Michelle Monje , Kathrynr Taylor , Estefania Luna Figueroa , Department Of Neurosurgery , Baylor College Of Medicine , Baylor College Of Medicine Or Stanford University , Baylor College , Cancer Neuroscience ,

Researchers identify novel gene mechanism in most aggressive kidney cancers

In a new study from the Johns Hopkins Kimmel Cancer Center, researchers described a novel mechanism of tumor formation in kidney cancers driven by overexpression of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway with loss of the tuberous sclerosis complex (TSC) tumor suppressor gene. ....

Pedram Argani , Adriannaa Mendes , Tamara Lotan , Ethan Schaffer , Thiago Vidotto , Sanjana Murali , Emily Henderson , Clarence Rachel Villanueva , Kaushal Asrani , Hansb Liu , Kewen Feng , Danielac Salles , Nature Communications , Johns Hopkins Kimmel Cancer Center , Johns Hopkins University School Of Medicine , Industry Focus , Juhyung Woo , Lia Oliveira , Brandon Lam , Johns Hopkins University School , Ignaling Pathway , Transcription Factors , Tuberous Sclerosis ,