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Objective To investigate the risk of non-alcoholic fatty liver disease (NAFLD) for cardiovascular disease and all cause death in patients with type 2 diabetes mellitus (T2DM).

Design Nationwide population based study.

Setting Longitudinal cohort study in Korea.

Participants 7 796 763 participants in the National Health Screening Programme in 2009 were divided into three groups based on NAFLD status: no NAFLD (fatty liver index<30); grade 1 NAFLD (30≤fatty liver index<60); and grade 2 NAFLD (fatty liver index≥60). Median follow-up was 8.13 years.

Main outcome measures The primary outcome was incident cardiovascular disease (myocardial infarction, ischaemic stroke) or all cause death.

Results Of 7 796 763 participants, 6.49% (n=505 763) had T2DM. More patients with T2DM had grade 1 NAFLD (34.06%) and grade 2 NAFLD (26.73%) than those without T2DM (grade 1 NAFLD: 21.20%; grade 2 NAFLD: 10.02%). The incidence rate (per 1000 person year ....

Kyung Soo Kim , Sangmo Hong , Kyungdo Han , National Health Information Database , National Death Registry , Soongsil University , National Health Insurance Service , National Health Screening Programme , Young Park , Icy Park , National Health Screening , National Death , Chronic Kidney Disease Epidemiology Collaboration , Open Access , Creative Commons Attribution Non Commercial ,