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IOF and IFCC review describes the current status of assays for reference bone turnover markers

IOF and IFCC review describes the current status of assays for reference bone turnover markers
Bone turnover markers (BTMs) in blood and urine are useful tools in monitoring osteoporosis treatment effects and may be useful for improving patient adherence.
In 2011, a Joint Committee on Bone Metabolism of the International Osteoporosis Foundation (IOF) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) designated Procollagen type I N-propeptide (PINP) and the C-terminal telopeptide of type I collagen (β-CTX) in blood as reference bone turnover markers for bone formation and bone resorption, respectively, in osteoporosis. However, the effective clinical implementation of these recommendations requires the standardization/harmonization of commercial assays. ....

Samuel Vasikaran , Nicholas Harvey , Emily Henderson , International Osteoporosis Foundation , Committee Of Bone Markers , Committee Of Scientific Advisors , Laboratory Medicine , International Federation Of Clinical Chemistry , Committee On Bone Metabolism , Joint Committee , Bone Metabolism , International Federation , Clinical Chemistry , Etienne Cavalier , Bone Markers , Scientific Advisors , சாமுவேல் வாசீகரன் , நிக்கோலஸ் ஹார்வி , எமிலி ஹென்டர்சன் , சர்வதேச அஸ்டீயாப்ரோஸிஸ் அடித்தளம் , குழு ஆஃப் எலும்பு குறிப்பான்கள் , ஆய்வகம் மருந்து , சர்வதேச கூட்டமைப்பு ஆஃப் மருத்துவ வேதியியல் , குழு ஆன் எலும்பு வளர்சிதை மாற்றம் , கூட்டு குழு , எலும்பு வளர்சிதை மாற்றம் ,

IOF and IFCC review calls for harmonization of assays for reference bone turnover markers

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Bone turnover markers (BTMs) in blood and urine are useful tools in monitoring osteoporosis treatment effects and may be useful for improving patient adherence.
In 2011, a Joint Committee on Bone Metabolism of the International Osteoporosis Foundation (IOF) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) designated Procollagen type I N-propeptide (PINP) and the C-terminal telopeptide of type I collagen (β-CTX) in blood as reference bone turnover markers for bone formation and bone resorption, respectively, in osteoporosis. However, the effective clinical implementation of these recommendations requires the standardization/harmonization of commercial assays [1].
As well as a review of the structures of PINP and β-CTX molecules, the authors provide a succinct, referenced summary of current commercial assays, their descriptions, and performance characteristics. Key characteristics and performance specifications of the fou ....

Clin Chim Acta , Samuel Vasikaran , Nicholas Harvey , Committee For Bone Metabolism , International Osteoporosis Foundation , Committee Of Bone Markers , Committee Of Scientific Advisors , Laboratory Medicine , International Federation Of Clinical Chemistry , Committee On Bone Metabolism , Joint Committee , Bone Metabolism , International Federation , Clinical Chemistry , Professor Samuel Vasikaran , Etienne Cavalier , Bone Markers , Scientific Advisors , Clin Chim , Medicine Health , Internal Medicine , Metabolism Metabolic Diseases , Orthopedic Medicine , Pharmaceutical Chemistry , கிளினிக் சிம் ஆக்டா , சாமுவேல் வாசீகரன் ,