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Advanced mouse embryos grown outside the uterus


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To observe how a tiny ball of identical cells on its way to becoming a mammalian embryo first attaches to an awaiting uterine wall and then develops into nervous system, heart, stomach and limbs: This has been a highly-sought grail in the field of embryonic development for nearly 100 years. Prof. Jacob Hanna of the Weizmann Institute of Science and his group have now accomplished this feat. The method they created for growing mouse embryos outside the womb during the initial stages after embryo implantation will give researchers an unprecedented tool for understanding the development program encoded in the genes, and it may provide detailed insight into birth and developmental defects as well as those involved in embryo implantation. The results of this research were published in ....

Chen Itzkovich , Valeriya Chugaeva , Ilana Mantoux , Itay Maza , Alejandro Aguilera Castrejon , Mirie Zerbib , Rada Massarwa , Jonathan Bayerl , Saifeng Cheng , Jacob Hanna , Muneef Ayyash , Shadi Tarazi , Tom Shani , Zvia Zeroni , Hadas Keren Shaul , Raanan Shlomo , Shahd Ashouokhi , Lior Lasman , Daoud Sheban , Yoseph Addadi , Noa Novershtern , Yonatan Stelzer , Bernardo Oldak , Nir Livnat , Sergey Viukov , Israel Cancer Research Fund ,

Advanced Mouse Embryos Grown Outside Uterus


Weizmann Institute of Science
To observe how a tiny ball of identical cells on its way to becoming a mammalian embryo first attaches to an awaiting uterine wall and then develops into nervous system, heart, stomach and limbs: This has been a highly-sought grail in the field of embryonic development for nearly 100 years. Prof. Jacob Hanna of the Weizmann Institute of Science and his group have now accomplished this feat. The method they created for growing mouse embryos outside the womb during the initial stages after embryo implantation until more advanced stages will give researchers an unprecedented tool for understanding the development program encoded in the genes, and it may provide detailed insight into birth and developmental defects as well as those involved in embryo implantation. The results of this research were published in Nature. ....

Chen Itzkovich , Valeriya Chugaeva , Itay Maza , Alejandro Aguilera Castrejon , Mirie Zerbib , Rada Massarwa , Jonathan Bayerl , Muneef Ayyash , Saifeng Cheng , Jacob Hanna , Tom Shani , Shadi Tarazi , Hadas Keren Shaul , Raanan Shlomo , Shahd Ashouokhi , Daoud Sheban , Lior Lasman , Yoseph Addadi , Yonatan Stelzer , Noa Novershtern , Bernardo Oldak , Nir Livnat , Sergey Viukov , Rambam Health Care Campus Of The Technion , Weizmann Institute Of Science , Rambam Medical Center ,